Results 81 to 90 of about 2,630,775 (356)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Attentive processing improves object recognition [PDF]

, 2009
The human visual system can recognize several thousand object categories irrespective of their position and size. This combination of selectivity and invariance is built up gradually across several stages of visual processing. However, the recognition of
Chikkerur, Sharat, Poggio, Tomaso, Serre, Thomas   +2 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Retinex Based Image Enhancement via General Dictionary Convolutional Sparse Coding

Applied Sciences, 2020
Retinex theory represents the human visual system by showing the relative reflectance of an object under various illumination conditions. A feature of this human visual system is color constancy, and the Retinex theory is designed in consideration of ...
Jongsu Yoon, Yoonsik Choe
doaj   +1 more source

A cooperative-relational approach to digital libraries [PDF]

Copyright @ 2007 Springer-Verlag, Berlin HeidelbergThis paper presents a novel approach to model-driven development of Digital Library (DL) systems. The overall idea is to allow Digital Library systems designers (e.g.
B. Berkem, D. Ellis, D. Lucarella, E.A. Fox, H.R. Turtle, J. Lara de, N. Reyes-Farfan, T.R. Kochtanek   +7 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Empirical Validation of the Saliency-based Model of Visual Attention

ELCVIA Electronic Letters on Computer Vision and Image Analysis, 2003
Visual attention is the ability of the human vision system to detect salient parts of the scene, on which higher vision tasks, such as recognition, can focus. In human vision, it is believed that visual attention is intimately linked to the eye movements
Nabil Ouerhani, Roman von Wartburg, Heinz Hugli, Rene Muri   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Wayfinding design in transportation architecture – are saliency models or designer visual attention a good predictor of passenger visual attention?

Frontiers of Architectural Research, 2020
In transportation architecture, wayfinding quality is a crucial factor for determining transfer efficiency and level of service. When developing architectural design concepts, designers often employ their visual attention to imagine where passengers will
Ran Xu, Haishan Xia, Mei Tian
doaj   +1 more source

Evaluating human performance modeling for system assessment: Promise and problems [PDF]

The development and evaluation of computational human performance models is examined. An intention is to develop models which can be used to interact with system prototypes and simulations to perform system assessment. Currently LR is working on a set of
Patterson, Robert W., Young, Michael J.
core   +1 more source