Results 161 to 170 of about 5,101,776 (315)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Location, Navigation and Coordination : Studies of Work Practice and Technology
, 2002 This thesis presents studies of work and discusses the relation between ethnographies of work and design of technology. Four papers based on studies from two different kinds of work settings are included.
Pettersson, Mårten
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Visualizing representations of work
, 2002 This paper discusses experience of representing work in different ways. In the ongoing discussion about how to make ethnographic findings available for design work on representations has been presented.
Pettersson, Mårten
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
How Does Digital Human Resource Management Foster a Sense of Relaxation Among Generation Z Employees? [PDF]
Behav Sci (Basel)Zhang H, Hou X, Zhao S.
europepmc +1 more source
“He Worked with Human Hands”. Work as Human Action and Christ’s Action
Scientia et FidesThe complexity of work in our time presents new challenges for a theology that understands this fundamental dimension of existence and gives it an integrating, truly human meaning and a path to holiness. In order to embrace all modern forms of work, a definition of work is proposed as an action that involves the whole person and leads to fulfilment ...
openaire +1 more source