Results 111 to 120 of about 501,302 (307)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Role of National and International Aid Organisations in Disability Rehabilitation in Conflict Areas: A Scoping Review

Journal of Clinical and Diagnostic Research
Introduction: Disability can result directly from displacement or conflict caused by war-related injuries or trauma, or indirectly from deterioration of medical services.
Doly Bokalial, P Swarna Kumari
doaj   +1 more source

The Iraqi Red Crescent [PDF]

Forced Migration Review, 2007
The Iraqi Red Crescent Society (IRCS ) is among thefew organisations working to assist displaced persons throughout Iraq.
Jamal Al-Karboli
doaj  

Australia in the UN Security Council [PDF]

Overview: In this Lowy Institute Analysis, Richard Gowan reviews Australia’s time as a non-permanent member of the Security Council. Gowan argues that while it has not changed the world, Australia has acquitted itself well, bringing extra rigour and ...
Richard Gowan
core  

Feasibility Study: Social Protection in South Central Somalia [PDF]

, 2014
In recent years, there has been a growing recognition by policy makers and the international development community that longer-term social protection programming has the potential to reduce poverty and inequality and serve as a foundation upon which ...
Mike Brewin, Sophia Dunn
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Clinical utility of low‑frequency piezoelectric thromboelastography for global hemostasis assessment and prediction of thrombo‑hemorrhagic complications

Journal of Education, Health and Sport
Background. Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), remains a major cause of preventable in‑hospital morbidity and mortality worldwide.
O. Tarabrin, R. Sukhonos, K. Kirpichnikova, Ye. Buhayenko, I. Hladkykh, O. Suslov   +5 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

From Thirst to Thrombosis? Effects of Preoperative Fasting Regimens on Coagulation in Benign Prostatic Hyperplasia Assessed by Low-Frequency Piezoelectric Thromboelastography

Journal of Education, Health and Sport
Background. Benign prostatic hyperplasia (BPH) is one of the most common urological diseases in elderly men and frequently requires invasive diagnostic procedures.
O. Tarabrin, O. Suslov, R. Sukhonos, Ye. Buhayenko, I. Hladkykh, K. Kirpichnikova   +5 more
doaj   +1 more source