Results 201 to 210 of about 26,381 (295)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Strengthening and sustaining gender-based violence (GBV) coordination in emergencies: a synthesis of practitioner-driven, globally applicable recommendations. [PDF]

Confl Health
Raftery P, Potts A, Hyde M, Wuyke YY, Hashmey H, Munezero L, Kiss L, Hossain M, Palmer J.   +8 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

14 Delivering humanitarian assistance in the face of climate change – a qualitative study

BMJ Open
Peter Winch, Shannon McMahon, Joacim Rocklöv, Patricia Nayna Schwerdtle, Alix Faddoul, Carol Devine   +5 more
doaj   +1 more source

Analytical policy commentary: Multi-prong strategies for effective climate-resilient community-based health programming in humanitarian settings and beyond. [PDF]

J Clim Chang Health
Gebremeskel AT, Assefa M, Ormel I, Nyamuda L, Maurya BP, Sohani S.   +5 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Co-creating a decision-making framework for primary healthcare models in conflict-affected Cameroon and Nigeria. [PDF]

BMJ Glob Health
Omam LA, Alain M, Wudiri Z, Moustapha CA, Nuraini A, Asimiya SS, O'Laughlin KN, Ambebe R, Alfred J, Jarman E, Martin S, Njingu AE, Musa I, Fuen FM, Choupo L, Andu L, Manuel S, Acha-Morfaw O, Fuh CE, Nicholas T, Idrissou M, Mohammed H, Van Bortel T, Parkes-Ratanshi R.   +23 more
europepmc   +1 more source

The humanitarian ethos in action [PDF]

International Review of the Red Cross, 2015
openaire   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Policy and Structural Drivers of Malnutrition in Afghan Women: Evidence and Interventions. [PDF]

Int J Womens Health
Fayez SM.
europepmc   +1 more source