Results 81 to 90 of about 26,381 (295)

Coordination in urban humanitarian response

Progress in Disaster Science, 2019
This paper discusses the challenges of humanitarian coordination in crises situations in urban areas. It identifies the range of stakeholders and the central role of local authorities. It discusses the cluster system and its limitations in urban response.
David Sanderson
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Hacia una acción humanitaria más humana. La protección de derechos humanos por organizaciones humanitarias en situaciones de conflicto

Deusto Journal of Human Rights, 2017
With the end of the Cold War, we have seen both the emergence of new approaches and debates around Humanitarian Action, and a massive violation of the Human Rights of civil populations. These dynamics have stirred up the need to prioritise the protection
Alexandra Lages Miguel
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Humanitarianism and the Sendai Framework: A 10-Year Review of Converging and Diverging Paths

International Journal of Disaster Risk Science
Humanitarian action and disaster risk reduction are essential in addressing global vulnerability to disasters and crises. The Sendai Framework for Disaster Risk Reduction 2015–2030 (SFDRR), adopted in 2015, has garnered significant attention for its role
Rodrigo Mena
doaj   +1 more source

Beyond gender mainstreaming: transforming humanitarian action, organizations and culture. [PDF]

J Int Humanit Action, 2023
Gupta GR, Grown C, Fewer S, Gupta R, Nowrojee S.   +4 more
europepmc   +1 more source

Blurring the Lines? International Humanitarian Non-Governmental Organisations and the Military use of Aid and Development in Afghanistan

, 2010
This thesis explores the theory that International Humanitarian Non-governmental Organisations (IHNGOs) have increasingly become part of the world-ordering security agenda of developed western states since the end of the Cold War.
Jagger, Stanley Jeremy, Jagger, Stanley Jeremy   +1 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Rethinking democracy in global network governance: norm polysemy, pluralism, and agonistic engagement

International Theory
This article examines the democratic potential of global network governance. It critiques conventional legitimacy frameworks that focus on the institutional qualities of governance networks for evading deeper ethical questions about how to deal with ...
Kilian Spandler
doaj   +1 more source