Results 191 to 200 of about 223,141 (305)

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Correction: Impact of Ebola and COVID‑19 on maternal, neonatal, and child health care among populations affected by conflicts: a scoping review exploring demand and supply‑side barriers and solutions

Conflict and Health
Yasir Shafiq, Elena Rubini, Zoha Zahid Fazal, Muhammad Murtaza Bukhari, Maheen Zakaria, Noor ul Huda Zeeshan, Ameer Muhammad, Luca Ragazzoni, Francesco Barone‑Adesi, Martina Valente   +9 more
doaj   +1 more source

The occurrence of and factors associated with mental ill-health amongst humanitarian aid workers: A systematic review and meta-analysis. [PDF]

PLoS One
Cameron L, McCauley M, van den Broek N, McCauley H.   +3 more
europepmc   +1 more source

Challenges and barriers of humanitarian aid management in 2017 Kermanshah earthquake: a qualitative study. [PDF]

BMC Public Health, 2020
Safarpour H, Fooladlou S, Safi-Keykaleh M, Mousavipour S, Pirani D, Sahebi A, Ghodsi H, Farahi-Ashtiani I, Dehghani A.   +8 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Advancing Global Health Equity: Saudi Arabia’s Leadership in Conjoined Twins Care and Humanitarian Outreach

Journal of Epidemiology and Global Health
Abdullah A. Al Rabeeah, Ziad A. Memish
doaj   +1 more source

Trust in Humanitarian Aid From the Earthquake in 2017 to COVID-19 in Iran: A Policy Analysis. [PDF]

Disaster Med Public Health Prep, 2020
Seddighi H.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source