Results 41 to 50 of about 278,661 (297)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Autonomous weapon systems and international humanitarian law: a reply to the critics [PDF]

, 2013
In November 2012, Human Rights Watch, in collaboration with the International Human Rights Clinic at Harvard Law School, released Losing Humanity: The Case against Killer Robots.[2] Human Rights Watch is among the most sophisticated of human rights ...
Schmitt, Michael
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Common Legislation in Islamic Countries on Humanitarian Law [PDF]

پژوهش تطبیقی حقوق اسلام و غرب, 2017
There are many potentials in Islamic countries legal systems to pace toward legal integration. One of them is common resources of law which can be used to have “Common Legislation”.
Seyed Ahmad Habibnezhad, Mohammad Saleh Taskhiri   +1 more
doaj   +1 more source

Aspek Hukum Humaniter Dalam Krisis Kemanusiaan Terhadap Anak Di Kolombia Tahun 2012-2015 [PDF]

, 2016
This research describes humanitarian law aspects in human crisis toward child in Colombia in 2012-2015. Colombia are state in Latin America region. Since 1964, Government of Colombia have crisis withe the separatism grouo that name a Fuerzas Armadas ...
Afrizal, A. (Afrizal), Maulana, T. R. (Tengku)   +1 more
core  

The United Nations Security Council and the enforcement of international humanitarian law [PDF]

, 2010
This Article discusses the competences and powers of the UN Security Council in securing compliance with international humanitarian law, in particular through the adoption of the measures provided in Chapter VII of the Charter: The competence of the ...
A. van Baarda, Abi-Saab, Arangio-Ruiz, Arangio-Ruiz, Biersteker, Bothe, Bourloyannis, Cannizzaro, Condorelli, Cryer, de Chazournes, de Chazournes, De Wet, Fassbender, Franck, Fry, Gaja, Gaja, Gardam, Gasser, Gattini, Gill, Gray, Herdegen, Holt, Kalshoven, Kelsen, Kolb, Kolb, Lamb, Meron, Michaelsen, Mosler, Pfanner, Picone, Pocar, Porretto, Roberts, Roscini, Sandoz, Scelle, Schotten, Schwebel, Wellens, Winkelmann, Wolfrum, Zemanek, Zwanenburg, Österdahl, Österdahl   +49 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Humanitarian Intervention in International and Islamic Law

American Journal of Islam and Society, 2003
In this paper, I look into the moral foundation of humanitarian intervention in international law and its Islamic counterpart. My objective is to identify the traits shared by both sets of laws, and to see if the same or similar justification can be used
Ermin Sinanovic
doaj   +1 more source

Humanitarian Financial Intervention

, 2013
Over the past several decades, states have used international asset freezes with increasing frequency as a mechanism for promoting human rights abroad.
Criddle, Evan J.
core   +1 more source