Results 61 to 70 of about 52,504 (341)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Two-Stage Humanitarian Logistics Deprivation Model for the Planning of Scarce KN-95 Facemask Supplies under Agent’s Cooperation

Journal of Advanced Transportation, 2021
Humanitarian logistics encompasses a wide spectrum of conditions or constraints for supply chains, yet its focus on mitigating human suffering efficiently is what has motivated organizations and governments to make rapid decisions in real time.
Oscar L. Pineda-Martinez, Carlos D. Paternina-Arboleda, Guisselle A. García-Llinás   +2 more
doaj   +1 more source

Performance measurement in humanitarian logistics [PDF]

, 2013
The purpose of this paper is to provide the (humanitarian) logistics community with ideas how performance measurement can be applied in humanitarian ...
Bölsche, Dorit
core  

Using Force on Land to Suppress Piracy at Sea: The Legal Landscape of a Largely Untapped Strategy [PDF]

, 2013
On May 14, 2012, a combat helicopter operated by European Union Naval Forces (EUNAVFOR) struck a pirate base ashore in Somalia. The raid destroyed several fiberglass skiffs on the beach in Haradheere, a town on the coast of central Somalia.
Obert, Steven R.
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Supply chain management in a messy context: the case of humanitarian logistics [PDF]

, 2015
Based on literature on "wicked" (Rittel and Webber 2007) or "messy" problems (Ackoff 1981) a conceptual framework for “messy supply chains” is developed. Findings from a series of semi-structured interviews explore the presence and potential effects of
Caldwell, Nigel, Piecyk, Maja, Schiffling, Sarah   +2 more
core  

Agile and lean principles in the humanitarian supply chain [PDF]

Journal of Humanitarian Logistics and Supply Chain Management, 2012
Purpose – – The purpose of this paper is to identify the specific stages of the humanitarian logistics process in which the agile and lean principles are needed. Design/methodology/approach – – To achieve this purpose, the authors propose an original
Alessandra Cozzolino, Silvia Rossi, Alessio Conforti   +2 more
doaj   +1 more source

Social, administrative and educational dimensions of the “human – subject of economic life” phenomenon under conditions of information society transition to a new level of development [PDF]

, 2020
Перехід інформаційного суспільства на новий рівень розвитку в тріаді генезисних процесів «становлення – формування – розвиток» спричинює численні зміни.
Голодюк, Л. С., Мієр, Тетяна Іванівна   +1 more
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source