Results 161 to 170 of about 1,461,417 (388)

Information seeking in the Humanities: physicality and digitality [PDF]

open access: yes, 2008
This paper presents a brief overview of a research project that is examining the information seeking practices of humanities scholars. The results of this project are being used to develop digital resources to better support these work activities ...
Blandford, A.   +4 more
core  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Life on a Nickels Edge Struggle and Dignity in Buffalo\u27s Fruit Belt [PDF]

open access: yes, 2017
This purpose of this fact sheet is to give a brief overview of the Fruit Belt neighborhood on Buffalo’s East Side in relation to community demographics, development, and efforts to control land use through the creation of the FB Community Land Trust ...
Marsland, John
core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

No Time to Defend the Pre-Post-Truth World [PDF]

open access: yes, 2017
As much as the post-truth needs to be challenged and countered, the humanities can play a crucial role in keeping alive the understanding that the pre-post-truth world ought not to be conserved, but transformed positively.
Pickard, Richard
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

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