Results 201 to 210 of about 1,461,417 (388)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Identidade profissional e as humanidades na Famed/UFU
Revista Brasileira de Educação MédicaEste ensaio aborda a identidade no âmbito da educação, em particular a identidade profissional do médico e suas relações com o curso de formação em Medicina da Universidade Federal de Uberlândia (UFU).
Alfredo Demétrio Jorge Neto
doaj
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Slopek, Edward. Bodies of Art: The Shaping of Aesthetic Experience
Belphégor, 2022 Marie Pascal
doaj +1 more source
MedEdPublish, 2018 Whether the arts have any value in the medical curriculum continues to be debated. This article presents the author's views on the use of the arts, the principal contention being that the arts (the humanities) can teach us a lot about the art of medicine.
George Zaharias
doaj
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source