Results 201 to 210 of about 84,220 (268)

Beyond Communication: Expressing the Language of Humanity in Medicine. [PDF]

Perspect Med Educ
Apondo S.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Reflections on racism, civility, and the role of general practice. [PDF]

Br J Gen Pract
Singh C.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Rediscovery of animality in the concept of sport: a posthuman perspective. [PDF]

Front Sports Act Living
Sakamoto T, Sato Y.
europepmc   +1 more source

Hidden Curriculum in Silence. [PDF]

Fam Med
Sai VH.
europepmc   +1 more source

Therapeutic misalignment averted by clonal evolutionary evidence: molecular confirmation of hepatic metastasis in SMARCA4-deficient non-small cell lung cancer initially misdiagnosed as resectable cholangiocarcinoma. [PDF]

Front Oncol
Fan R, Zhan Y, Yan J, Gao J.
europepmc   +1 more source

Correction: Comparing the performance of radiomics, nomograms, machine learning, and large language models in predicting 28-day mortality in severe community-acquired pneumonia patients. [PDF]

Front Immunol
Lin T, Wan H, Liang Y, Ming J, Lu J, Guo Z.   +5 more
europepmc   +1 more source