Results 91 to 100 of about 61,570 (310)
Advanced Science, EarlyView.The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen +15 more
wiley +1 more source
The integration paradigm of geography
Časopis Socìalʹno-Ekonomìčnoï Geografìï. Часопис соціально-економічної географії, 2016 The processes of natural and humanitarian integration in the geography are described. The humanistic geography (or human geography, anthropogeography), is seen as an integrating methodology for geography which combines the principles of natural sciences
Alexander Gladkey, Iurii Golubchikov
doaj +1 more source
The External Dimension of EU Citizenship: Arguing for Effective Protection of Citizens Abroad. CEPS Policy Brief No. 136, 3 July 2007 [PDF]
, 2007 [From the Introduction]. This Policy Brief is the edited and extended version of CEPS’ contribution to the Commission’s Green Paper consultation. While acknowledging that the Green Paper addresses a wide range of issues, this document focuses mainly on ...
Geyer, Florian.
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Tabhu: tools for antibody humanization. [PDF]
, 2014 Antibodies are rapidly becoming essential tools in the clinical practice, given their ability to recognize their cognate antigens with high specificity and affinity, and a high yield at reasonable costs in model animals.
Marcatili, Paolo +2 more
core +2 more sources
Advanced Science, EarlyView.Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian +13 more
wiley +1 more source
Bioethics and the humanization of healthcare services
Revista Colombiana de Bioética, 2015 The circumstances that relate to the reality of the human being put him in opposition with his humanization, that is to say, in contrast with his humanism.
Carlos Andrés Andino Acosta
doaj +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Some Aspects about the Relationship between Productivity and Work Humanization [PDF]
It is widely recognized that job dissatisfaction leads to a protest movement, directed generally towards technology and management. Job dissatisfaction was and still is determined mostly by dehumanizing the nature of work; work should be as natural as ...
Adina Letitia NEGRUSA, Gh. Gh. IONESCU
core
, 2019 In this review, we summarize the current knowledge concerning the eukaryotic protozoan parasite Leishmania tarentolae, with a main focus on its potential for biotechnological applications.
Klatt, S. +3 more
core +1 more source
Humanitarianism, humanity, human [PDF]
Journal of Human Rights, 2003 (2003). Humanitarianism, humanity, human. Journal of Human Rights: Vol. 2, No. 2, pp. 253-258.
openaire +1 more source