Results 61 to 70 of about 23,799 (303)

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Moved by Observing the Love of Others: Kama Muta Evoked Through Media Fosters Humanization of Out-Groups

Frontiers in Psychology, 2020
People often view out-groups as less human than their in-group. Some media video content is heart-warming and leaves one feeling touched or moved. Recent research indicates that this reflects a positive social emotion, kama muta, which is evoked by a ...
Johanna K. Blomster Lyshol, Lotte Thomsen, Lotte Thomsen, Beate Seibt, Beate Seibt   +4 more
doaj   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

Conceptualising quality early childhood education: Learning from young children in Brazil and South Africa through creative and play‐based methods

British Educational Research Journal, EarlyView., 2023
Abstract Early childhood has increasingly been acknowledged as a vital time for all children. Inclusive and quality education is part of the United Nations Sustainable Development Goals, with the further specification that all children have access to quality pre‐primary education.
Laura H. V. Wright, Irene Rizzini, Malibongwe Gwele, Lynn McNair, Cristina Laclette Porto, Marsha Orgill, E. Kay M. Tisdall, Malcolm Bush, Linda Biersteker   +8 more
wiley   +1 more source

Humanization, Adaptation to Change, and Mental Health in Teachers in Three European Countries

European Journal of Psychology Applied to Legal Context
Background: The aim of this study was to explore the relationships between humanization, adaptability to change, and mental health in European teachers (Spanish, Portuguese, and Italian teachers), as well as the relationship between humanization and ...
María M. Molero, África Martos, María C. Pérez-Fuentes, Begoña M. Tortosa, Maria Sisto, María M. Simón, José J. Gázquez   +6 more
doaj   +1 more source

CREATING THE SITUATION OF SUCCESS IN THE HUMAN SCIENCES – A PREREQUISITE FOR THE HUMANIZATION OF EDUCATION

Освітній дискурс, 2020
The problem of success became relevant at the beginning of the XXI century. Everyone strives to succeed, to be confident in themselves and in the future. Success is recognized as one of the needs of the individual.
Ayta Sakun, Tatiana Kadlubovich, Darina Chernyak   +2 more
doaj   +1 more source

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

De-umanizzazione (e umanizzazione) nelle relazioni intergruppi. La prospettiva della psicologia sociale sperimentale

Rivista Internazionale di Filosofia e Psicologia, 2011
De-humanization (and Humanization) in Intergroup Relations: The Perspective of Experimental Social Psychology - History, even in its more recent years, offers many examples of the denial of full humanity to a social group and its members.
Maria Paola Paladino, Jeroen Vaes
doaj  

Humanization strategies in pediatric intensive care

The international HU-CI project advocates eight strategic strands for the humanization of intensive care units. Despite of adult ICUs have received attention to promote humanization of care, in the pediatric context, the humanization of care continues to
Esther Salgado Reguero
core   +1 more source