Results 121 to 130 of about 8,757,604 (305)
Age of Human Rights JournalThis paper holds that teacher training constitutes a binding preventive obligation arising from Articles 19 and 34 of the Convention on the Rights of the Child, Article 5 of the Lanzarote Convention, and Article 23(3) of Directive 2011/92/EU ...
Alejandra Ramírez González
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Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
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BMC Veterinary ResearchPorcine reproductive and respiratory syndrome virus (PRRSV) induces a poor innate immune response following infection. This study evaluates the effects of transforming growth factor beta 1 (TGFβ1) up-regulated by PRRSV on gene expressions of co ...
Dante Fabros, Wasin Charerntantanakul
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
IEEE Transactions on Neural Systems and Rehabilitation EngineeringRobotic exoskeletons have advanced significantly, yet control systems still face challenges in delivering assistance that seamlessly aligns with the user’s musculoskeletal system.
Seongmi Song +2 more
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Co-Designing School Routes with Children: What Matters in Sensory Design for Wellbeing?
SocietiesChildren’s physical and mental wellbeing is declining, partly due to reduced independent mobility and lack of engaging public environments. This study explores a co-design approach in which children actively participated in a series of design workshops ...
Jessica Rohdin +3 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source