Results 241 to 250 of about 19,747,875 (398)

Investment in humans, technological diffusion and economic growth

, 1965
R. Nelson, E. Phelps
semanticscholar   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

One digital health through wearables: a viewpoint on human-pet integration towards Healthcare 5.0. [PDF]

Front Digit Health
Haghi M, Abani S, Khooyooz S, Jahanjoo A, Rashidibajgan S, TaheriNejad N, Deserno TM, Volk H.   +7 more
europepmc   +1 more source

Epidemiology and Clinical Associations of Human Parechovirus Respiratory Infections

, 2008
Heli Harvala, Ian Robertson, E. Carol McWilliam Leitch, Kimberley Benschop, Katja C. Wolthers, Kate Templeton, Peter Simmonds   +6 more
openalex   +1 more source

Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans [PDF]

, 2019
Stephan Sachs, Simona Zarini, Darcy Kahn, Kathleen A. Harrison, Leigh Perreault, Tzu Phang, Sean A. Newsom, Allison Strauss, Anna A. Kerege, Jonathan A. Schoen, Daniel H. Bessesen, Thomas Schwarzmayr, Elisabeth Graf, Dominik Lutter, Jan Krumsiek, Susanna M. Hofmann, Bryan C. Bergman   +16 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A qualitative risk assessment of Crimean-Congo haemorrhagic fever in Nigeria: implications for One Health response. [PDF]

Int Health
Egwuenu A, Makama S, Ahmed N, Igah O, Nwiyi G, Abioye Y, Kolade D, Okpala C, Emelife C, Okunromade O, Ilori E, Pantuvo J, Agogo E, Aruna O, Lucia Ochu C, Adetifa IMO.   +15 more
europepmc   +1 more source

Mapping Interactions of Microbial Metabolites with Human G-Protein-Coupled Receptors [PDF]

, 2019
Dominic A. Colosimo, Jeffrey A. Kohn, Peter Luo, Frank J. Piscotta, Sun M. Han, Amanda J. Pickard, Arka Rao, Justin R. Cross, Louis Cohen, Sean F. Brady   +9 more
openalex   +1 more source

The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans.

Cerebral Cortex, 2000
D. Öngür, J. Price
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source