Results 81 to 90 of about 8,757,604 (305)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Human niche, human behaviour, human nature [PDF]
Interface Focus, 2017 Abstract The concept of a ‘human nature’ or ‘human natures’ retains a central role in theorizing about the human experience. In Homo sapiens it is clear that we have a suite of capacities generated via our evolutionary past, and present, and a flexible capacity to create and sustain particular kinds of cultures and to be shaped by ...
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
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The Sensitivity of Language Models and Humans to Winograd Schema Perturbations
, 2020 Large-scale pretrained language models are the major driving force behind recent improvements in performance on the Winograd Schema Challenge, a widely employed test of common sense reasoning ability. We show, however, with a new diagnostic dataset, that
Abdou, Mostafa +5 more
core +1 more source
Victorian Literature and Culture, 2019 I first met Elaine Freedgood seven years ago, when she sent an abstract to me after her friend and colleague, Toral Gajarawala, came across a call for papers I had posted for an MLA session on fictional worlds. Since then, I've been just one of many people who have received tremendous behind-the-scenes support from Elaine, and I want to take some time ...
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
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Human arm redundancy: a new approach for the inverse kinematics problem
Royal Society Open ScienceThe inverse kinematics (IK) problem addresses how both humans and robotic systems coordinate movement to resolve redundancy, as in the case of arm reaching where more degrees of freedom are available at the joint versus hand level.
Avi Barliya +5 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
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Scientific ReportsDeep neural networks (DNNs) excel at extracting insights from complex data across various fields, however, their application in cognitive neuroscience remains limited, largely due to the lack of approaches with interpretability.
Murat Kucukosmanoglu +3 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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