Results 51 to 60 of about 815 (248)

Humidifier disinfectant: 78 deaths and still in progress.

open access: greenIranian journal of public health, 2013
Sh Yarahmadi   +3 more
openalex   +5 more sources

Eye irritation tests of polyhexamethylene guanidine phosphate (PHMG) and chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) using a tissue model of reconstructed human cornea-like epithelium [PDF]

open access: yesEnvironmental Health and Toxicology, 2019
Disinfectants including polyhexamethylene guanidine phosphate (PHMG) and mixtures of chloromethylisothiazolinone/ methylisothiazolinone (CMIT/MIT) have been widely used in Korea to prevent microbial growth in the humidifier water, which triggered an ...
Juyoung Park, Handule Lee, Kwangsik Park
doaj   +1 more source

Characteristics of a new respiratory syndrome associated with the use of a humidifier disinfectant: humidifier disinfectant-related respiratory syndrome (HDRS)

open access: yesInternational Journal of Occupational Medicine and Environmental Health, 2020
The purpose of this study was to characterize a new respiratory syndrome associated with exposure to a humidifier disinfectant (HD) in South Korea that is distinct from the well-known HD-related lung injury (HDLI). The authors identified this condition in 24 study subjects who were family members of patients with definite or probable HDLI (referred to ...
Jong Han Leem   +6 more
openaire   +3 more sources

New-Onset and Exacerbation of Lung Diseases after Short-Term Exposures to Humidifier Disinfectant during Hospitalization

open access: yesToxics, 2022
(1) Background: Humidifier disinfectant (HD) is a biocidal chemical to keep the water tank inside a humidifier clean. Thousands of Koreans have experienced HD-related lung injuries. Of them, 6.9% were exposed to HD in hospitals.
Seula Lee   +5 more
doaj   +1 more source

Developmental Toxicity and Thyroid Endocrine Disruption of Polyhexamethylene Guanidine Hydrochloride and Humidifier Disinfectant in Zebrafish Larvae

open access: yesApplied Sciences, 2021
Polyhexamethylene guanidine (PHMG), a major component of humidifier disinfectants (HDs), is responsible for the outbreak of pulmonary diseases in pregnant women and children in South Korea.
Suhyun Park, Hyojin Kim, Kyunghee Ji
doaj   +1 more source

MTF1 Is Essential for the Expression of MT1B, MT1F, MT1G, and MT1H Induced by PHMG, but Not CMIT, in the Human Pulmonary Alveolar Epithelial Cells

open access: yesToxics, 2021
The inhalation of humidifier disinfectants (HDs) is linked to HD-associated lung injury (HDLI). Polyhexamethylene guanidine (PHMG) is significantly involved in HDLI, but the correlation between chloromethylisothiazolinone (CMIT) and HDLI remains ...
Sang-Hoon Jeong   +13 more
doaj   +1 more source

Hematotoxic Effect of Respiratory Exposure to PHMG-p and Its Integrated Genetic Analysis

open access: yesToxics, 2022
Polyhexamethylene guanidine phosphate (PHMG-p), the main ingredient of humidifier disinfectants, circulates systemically through the lungs; however, its toxicological assessment has been primarily limited to pulmonary disease. Herein, we investigated the
Hwa Jung Sung   +12 more
doaj   +1 more source

Intratracheal exposure to polyhexamethylene guanidine phosphate disrupts coordinate regulation of FXR-SHP-mediated cholesterol and bile acid homeostasis in mouse liver

open access: yesEcotoxicology and Environmental Safety, 2022
A public health crisis in the form of a significant incidence of fatal pulmonary disease caused by repeated use of humidifier disinfectants containing polyhexamethylene guanidine phosphate (PHMG) recently arose in Korea.
You-Jin Choi   +10 more
doaj   +1 more source

NOTCH1Pathway is Involved in Polyhexamethylene Guanidine-Induced Humidifier Disinfectant Lung Injuries [PDF]

open access: yesYonsei Medical Journal, 2020
An outbreak of fatal humidifier disinfectant lung injuries (HDLI) occurred in Korea. Human studies on mechanisms underlying HDLI have yet to be conducted. This study aimed to investigate methylation changes and their potential role in HDLI after exposure to HDs containing polyhexamethylene guanidine-phosphate.
Eun Lee   +11 more
openaire   +2 more sources

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