Results 131 to 140 of about 1,012,376 (308)

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

Optimal Determining Air Supply Humidity for Multi-Location Demands Under Different Objectives in an Indoor Moisture Environment: A Comprehensive Method and Case Study

open access: yesBuildings
Within high-precision indoor environments, such as semiconductor fabrication or textile plants, humidity control is paramount for preserving product integrity and reducing energy expenditure.
Xiaojun Ma   +3 more
doaj   +1 more source

Simulation of a model-based optimal controller for heating systems under realistic hypothesis [PDF]

open access: yes, 2005
An optimal controller for auxiliary heating of passive solar buildings and commercial buildings with high internal gains is tested in simulation. Some of the most restrictive simplifications that were used in previous studies of that controller (Kummert ...
Andre, Philippe, Kummert, Michael
core  

Temperature-Controlled Humid Storage Room

open access: yes, 1976
The design of a soil sample storage room that has been in operation since 1954 is described. The room provides a storage environment with a constant temperature of 55 °F and relative humidities of 90 – 97 percent. It is of wood frame construction, lined with copper sheeting, forming a watertight interior.
openaire   +3 more sources

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan   +9 more
wiley   +1 more source

Method of evaluating moisture barrier properties of encapsulating materials Patent [PDF]

open access: yes, 1970
Method of evaluating moisture barrier properties of materials used in electronics ...
Ellern, W. B.
core   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

open access: yesArthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni   +7 more
wiley   +1 more source

Strain rate, temperature, and humidity on strength and moduli of a graphite/epoxy composite [PDF]

open access: yes
Results of an experimental study of the influence of strain rate, temperature and humidity on the mechanical behavior of a graphite/epoxy fiber composite are presented. Three principal strengths (longitudinal, transverse and shear) and four basic moduli (
Lifshitz, J. M.
core   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

open access: yesAdvanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio   +11 more
wiley   +1 more source

Subsystem trade-off environmental control and life support for orbiter phase B contractor [PDF]

open access: yes, 1971
Environmental control and life support subsystem for space shuttle ...
Augusti, R., Jasin, J.
core   +1 more source

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