Results 61 to 70 of about 168,045 (292)

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Beyond Tweets: Pragmatic Analysis of Humor as a Brand Image in Burger King’s Tweets

Journal of Urban Society's Arts, 2019
Melebihi Tweet: Analisis Pragmatis Humor sebagai Citra Merek di Tweet Burger King. Salah satu bentuk strategi komunikasi yang paling populer adalah humor.
Marti Fauziah Ariastuti, Amadhea Naidriya Putri   +1 more
doaj   +1 more source

In Japan, individuals of higher social class engage in other-oriented humor

Scientific Reports, 2022
Previous research on individual social class (SC) and humor has found support for the hypothesis that those with higher SC will engage in more dominant humor (aggressive humor) that derogates or degrades others.
Ryota Tsukawaki, Tomoya Imura, Makoto Hirakawa   +2 more
doaj   +1 more source

Perceived related humor in the classroom, student–teacher relationship quality, and engagement: Individual differences in sense of humor among students

Heliyon, 2023
This study explored the effect of humor on teacher–student relationship quality (TSRQ) and student engagement by uncovering the mediating role of TSRQ and the moderating role of individual differences (personal sense of humor).
Lu'mu, Ani Cahyadi, Muhammad Ramli, Ruslan, Hendryadi   +4 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Using humor to disguise racism in television news : The case of the Roma

, 2022
It has been argued that more research is needed on the role of humor in the expression of racism. One reason is that, in the ‘post racial’ society, overt racism has become publicly unacceptable and, therefore, tends to appear in more concealed forms.
Breazu, Petre,, Machin, David,
core   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

The rhetoric of disparagement humor: An analysis of anti-semitic joking online [PDF]

, 2015
Studies of humor informed by an understanding of rhetoric offer a number of conceptual tools for the analysis of disparagement humor. This article examines recent rhetorical approaches to humor analysis and evaluates their strengths and weaknesses. Where
Simon Weaver, Weaver, S
core   +1 more source

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, EarlyView.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source

Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature

Advanced Science, EarlyView.
A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo, Yangyang Zhang, Yongcheng Jin, Siwei Deng, Yongqi Chen, Zheng Feng, Hao Wen, Liu Wang, Yilin Li, Fanghong Ou, Yong Shen, Haiming Li, Tianyao Zhou, Xingzhu Ju, Xiaohua Wu   +14 more
wiley   +1 more source