Results 101 to 110 of about 293,719 (313)

Real‐time monitoring of root dielectric properties for assessing crop plant damage caused by foliar application of glyphosate

open access: yesApplications in Plant Sciences, EarlyView.
Abstract Premise There is a knowledge gap regarding how foliar injury and restricted water uptake can be detected by measuring root dielectric response. This pot study nondestructively evaluated the efficiency of real‐time dielectric measurement to monitor the effects of glyphosate spraying.
Imre Cseresnyés   +2 more
wiley   +1 more source

Early Pliocene Varanus (Squamata, Varanidae) remains from Megalo Emvolon, Thessaloniki, Greece

open access: yesThe Anatomical Record, EarlyView.
The article describes new cranial and postcranial varanid material from Megalo Emvolon Lower Pliocene vertebrate fossil site near Thessaloniki. The fossils, likely representing a single individual, are referred to Varanus cf. marathonensis. Abstract This study describes new fossil varanid material from a recently discovered fossil spot (MVL site) at ...
Chara Drakopoulou   +3 more
wiley   +1 more source

Combination Therapy in Participants With Active Psoriatic Arthritis Using Subcutaneous Guselkumab and Golimumab: Week 24 Results From a Phase 2a, Multicenter, Randomized, Double‐Blind, Proof‐of‐Concept Study

open access: yesArthritis &Rheumatology, EarlyView.
Objective To assess guselkumab + golimumab combination therapy versus guselkumab monotherapy in participants with active psoriatic arthritis (PsA) and inadequate response to tumor necrosis factor inhibitors (TNFi‐IR). Methods Adults with active TNFi‐IR PsA (three or more tender/swollen joints) were randomized (2:1) to subcutaneous guselkumab (100 mg) +
Jose U. Scher   +12 more
wiley   +1 more source

The THESEUS Space Mission and the Infrared Telescope Calibration Unit

open access: yesAstronomische Nachrichten, EarlyView.
ABSTRACT The Transient High‐Energy Sky and Early Universe Surveyor (THESEUS) is an ESA M7 mission concept currently in Phase A, designed to exploit gamma‐ray bursts to probe the early Universe while advancing multi‐messenger and time‐domain astrophysics. To achieve its ambitious goals, THESEUS will combine wide‐band x‐ray and gamma‐ray monitors with an
András Péter Joó   +9 more
wiley   +1 more source

The Network Model of Mentalization, Social Vulnerability, and the Self in Autism: A Comparison With Neurotypical Adults

open access: yesAutism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is characterized by alterations in social understanding and self‐related experience that overlap with broader dimensions of psychosocial vulnerability. These domains are tightly interconnected, motivating the use of analytic approaches that can capture their organization as complex associations rather than as ...
Szilárd Holka   +4 more
wiley   +1 more source

Lower Striatal and Cortical Calretinin Interneuron Density Associated With Altered Social Behavior in Cntnap2 Knockout Mice

open access: yesAutism Research, EarlyView.
ABSTRACT Variants in the CNTNAP2 gene, encoding the cell adhesion molecule CASPR2, have been identified as genetic risk factors for autism spectrum disorder (ASD). However, the mechanisms through which CNTNAP2 dysfunction alters circuit function remain unknown.
Krisztina Sáfár   +10 more
wiley   +1 more source

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló   +5 more
wiley   +1 more source

Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley   +1 more source

How the HTAR will contribute to a value‐based decision‐making for medicinal products across the EU

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
The European Union Health Technology Regulation 2021/2282 (HTAR) introduces joint assessment of health technologies (including medicinal products and medical devices) across EU Member States. It was signed into law in 2021 and came into full force in January 2025.
Roisin Adams, Michal Stanak
wiley   +1 more source

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