Results 71 to 80 of about 357,115 (266)

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

The Intelligibility of Referendum Issues and the Opportunities to Inform Voters. Comparative Observations with Special Regard to Hungary

Annales Universitatis Mariae Curie-Skłodowska. Sectio K, Politologia, 2019
The intelligibility of initiative proposals is of utmost importance in case of direct democratic decisions. This study sums up the tools by means of which voters are informed about referendum issues in countries or states with well developed direct ...
László Komáromi, Gabriella Antalicz
doaj   +1 more source

Macroeconomic Factors and Capital Markets. Selected Experiences in Central and Eastern Europe

Management Dynamics in the Knowledge Economy, 2020
The relationship between capital markets and macroeconomic variables is well documented in developed financial markets, but still developing in emerging financial markets.
Nicolescu Luminița
doaj   +1 more source

Adaptive Network Stabilization Despite Profound Structural Reorganization in Human Organotypic Cultures

Advanced Science, EarlyView.
Adult human organotypic cortical slices undergo marked neuronal loss, laminar disruption, and glial activation, yet their network activity progressively stabilizes after a variable period. Electrophysiology, longitudinal calcium imaging, and quantitative histology show that structurally remodeled human circuits show adaptive capacity resulting in ...
Estilla Zsófia Tóth, Rebeka Stelcz, Réka Bod, Ábel Petik, Eszter Juhász, Kinga Tóth, Liza Szalai, Nour Essam, Fanni Somogyi, Beatrix Kovács, Amirmahdi Mojtahedzadeh, Attila György Bagó, Loránd Erőss, Péter Orbay, Johanna Petra Szabó, Dániel Fabó, Boglárka Hajnal, Bence Rácz, Daniel Hillier, István Ulbert, Lucia Wittner   +20 more
wiley   +1 more source

A comparison of Ukrainian and Hungarian school-leaving English exams

Науковий Вісник Південноукраїнського Національного Педагогічного Університету імені К. Д. Ушинського
Annually, hundreds of millions of students worldwide face the crucial moment of their scholastic progression: matriculation examinations. These important assessments, often a critical gateway to tertiary education, influence future pathways of countless ...
Huszti Ilona, Kacsur Annamária
doaj   +1 more source

Polarization Holographic 4D Phenotyping Reveals Nanoplastic Induced Dysfunction in Zooplankton

Advanced Science, EarlyView.
Contaminant‐induced dysfunction in complex aquatic organisms remains difficult to resolve across scales. Polarization Holographic Imaging Microscopy (PHIM) integrates polarization‐sensitive holography with computational volumetric reconstruction for label‐free phenotyping of zooplankton in natural seawater, revealing that nanoplastic stress drives ...
Yuxing Li, Yanmin Zhu, Jingyan Chen, Rongzhou Chen, Yuen‐Wa Ho, Chutian Wang, James Kar‐Hei Fang, Kevin K. Tsia, Edmund Y. Lam   +8 more
wiley   +1 more source

Modulation of the TGF‐β/Smad Signaling Pathway by a Bioactive Oxidized Polygonati Rhizoma Polysaccharide Crosslinked Chitosan Hydrogel as Therapeutic Carrier for Parkinson's Disease Treatment

Advanced Science, EarlyView.
An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai, Jikuang Zhao, Chang Xue, Kailei Xu, Liang Yong, Zhuangwei Zhang, Yi Huang, Jianwei Shuai, Xianzhen Chen, Sheng Nie, Junpeng Xu   +10 more
wiley   +1 more source

The protection of the EU’s financial interests against violations of the rule of law in the Member States

International Journal of Management and Economics
Serious violations of the rule of law occurring in Hungary from 2010 to the present, as well as in Poland from 2015 to December 2023, have become a threat to the financial interests of the European Union (EU).
Oręziak Leokadia
doaj   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Heritagizing the Countryside in Hungary

Acta Universitatis Sapientiae: European and Regional Studies, 2018
For long decades in Hungary, not just the inhabitants and their lifestyles but the buildings of the villages were seen as outdated; only small details found their ways as decorative elements of representative architectural styles.
Harlov-Csortán Melinda
doaj   +1 more source