Results 121 to 130 of about 161,890 (272)

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Double Valve Replacement in a Patient With Hunter Syndrome. [PDF]

Cureus, 2022
Keshavamurthy S, Duncan A, Kumar A, Trombetta C, Rodriguez R, Tan C, Roselli E.   +6 more
europepmc   +1 more source

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

The FEBS Journal, EarlyView.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Airway Findings in Patients with Hunter Syndrome Treated with Intravenous Idursulfase. [PDF]

J Clin Med, 2023
De Vuyst R, Jalazo E, Tsujimoto TM, Lin FC, Muenzer J, Muhlebach MS.   +5 more
europepmc   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

The Efficacy of Intracanal Medicaments Within the Regenerative Endodontic Procedures on Permanent Necrotic Immature Teeth: Systematic Review and Naïve Indirect‐Comparison Meta‐Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Objectives The objectives of this study were to estimate and compare the 1‐year clinical success rates of triple antibiotic paste (TAP), double antibiotic paste (DAP), calcium hydroxide (CH) within regenerative endodontic procedures (REPs) on permanent necrotic immature teeth.
Mario Alovisi, Paolo G. Arduino, Stefano Petti   +2 more
wiley   +1 more source

Hunter Syndrome: The Phenotype of a Rare Storage Disease. [PDF]

Cureus, 2022
Sousa Martins R, Rocha S, Guimas A, Ribeiro R.   +3 more
europepmc   +1 more source

Advancing a relational perspective on leadership between neurotypical leaders and neurodivergent followers: An integrated systematic review and research agenda

International Journal of Management Reviews, EarlyView.
Abstract Leaders are widely positioned as cornerstones of neurodiversity inclusion within research and practice. Despite this, the management discipline remains plighted by lack of cohesive understanding regarding leadership in the context of neurodiversity—an issue only exacerbated by the fragmented nature of extant interdisciplinary research.
Mya Kirkwood, Laura Radcliffe, Joanne Lyubovnikova, Lilian Otaye‐Ebede   +3 more
wiley   +1 more source

An Infant Presenting with Interstitial Lung Disease Diagnosed Later as Hunter Syndrome: A Case Report. [PDF]

Am J Case Rep, 2022
AlTami B, AlKelabi H, Al-Qwaiee MM.
europepmc   +1 more source

The Experiences of Women With Polycystic Ovary Syndrome of the Healthcare They Receive: A Qualitative Systematic Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Background More than 12% of women worldwide are affected by polycystic ovary syndrome (PCOS), whose symptoms are similar to those of puberty, often leading to delayed diagnosis and missing the opportunity for early intervention. This not only puts PCOS women under physical and mental stress but also reduces their trust in doctors and makes ...
Baoying Zhang, Joan Lalor
wiley   +1 more source