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Huntington's disease: Brain imaging in Huntington's disease
2019Huntington's disease (HD) gene-carriers show prominent neuronal loss by end-stage disease, and the use of magnetic resonance imaging (MRI) has been increasingly used to quantify brain changes during earlier stages of the disease. MRI offers an in vivo method of measuring structural and functional brain change. The images collected via MRI are processed
Eileanoir B, Johnson, Sarah, Gregory
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Irritability in Huntington’s disease
Psychiatry Research, 2012Irritability is a frequent neuropsychiatric symptom in patients with Huntington's disease (HD). The Irritability Scale (IS) and the irritability factor of the Problem Behaviours Assessment (PBA) was used to assess irritability among 130 HD mutation carriers and 43 verified non-carriers. The IS was tested using receiver operating characteristic analysis
Reedeker, N. +6 more
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Huntington's disease – neuropathology
2011An expansion of a trinucleotide CAG repeat on chromosome 4 causes Huntington disease. The abnormal elongation of the CAG increases the polyglutamine stretch of huntingtin, which becomes proportionally toxic. The mutated huntingtin is ubiquitous in somatic tissues, yet the pathologic changes are apparently restricted to the brain.
Jean Paul G, Vonsattel +2 more
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2001
Huntington’s disease is a devastating autosomal-dominant neurodegenerative condition caused by the abnormal expansion of a polyglutamine tract in the huntingtin protein. Its epidemiology and clinical features are reviewed. A range of possible mechanisms for the disease is discussed and treatment prospects considered.
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Huntington’s disease is a devastating autosomal-dominant neurodegenerative condition caused by the abnormal expansion of a polyglutamine tract in the huntingtin protein. Its epidemiology and clinical features are reviewed. A range of possible mechanisms for the disease is discussed and treatment prospects considered.
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Predicting Huntington's disease
The Lancet, 1990R S, Shiwach, R H, Lindenbaum, A, Miciak
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