Results 181 to 190 of about 5,858 (232)

Administration of Huperzine A microspheres ameliorates myocardial ischemic injury via α7nAChR-dependent JAK2/STAT3 signaling pathway.

European Journal of Pharmacology, 2022
Acetylcholinesterase (AChE) inhibitor (AChEI) is well established as first-line agents for relieving the symptoms of Alzheimer's disease (AD). Injectable sustained-release formulation of AChEI may be suitable for treating AD patients. However, it needs to
Ce Zhang, Ming-An Li, Wei Xie, Min Li, Chunna You, Tian-tian Wang, Fenghua Fu   +6 more
semanticscholar   +1 more source

Pd-Catalyzed Direct Diversification of Natural Anti-Alzheimer's Disease Drug: Synthesis and Biological Evaluation of N-Aryl Huperzine A Analogues.

Journal of Natural Products, 2021
The first systematic direct diversification of a complex natural product by metal-catalyzed N-H functionalization was carried out. A new series of N-(hetero)aryl analogues (1-32) of the natural anti-Alzheimer's disease drug huperzine A (HPA) was prepared
Shi-Xing Miao, Linxi Wan, Zhen-Xiang He, Xian-Li Zhou, Xiaohuan Li, Feng Gao   +5 more
semanticscholar   +1 more source

Improved Protective Effects and Pharmacokinetics of Huperzine A Derivative H14 in Soman Poisoning: A Comparative Study With Huperzine A in Rats.

Rapid Communications in Mass Spectrometry
RATIONALE N-[2-Hydroxy-3,5-dimethylbenzilidene]-Hup A (H14) is a derivative of huperzine A (Hup A) that demonstrates superior protective effects against soman (GD) compared to Hup A. This study aims to evaluate the protective efficacy of H14 pretreatment
Guixiang Yang, Yalan Cui, Xingxing Zong, Qian Jin, Yi Zhang, Liqin Li, Dongxin Liu, Xuejun Chen, Chen Wang, Jingchen Wei   +9 more
semanticscholar   +1 more source

The effects of Huperzine A on dementia and mild cognitive impairment: An overview of systematic reviews

Phytotherapy Research, 2021
Cognitive impairments are a part of the neurocognitive disorders which deteriorate the normal cognitive function. An overview of systematic reviews (SRs) was conducted to summarize the findings of SRs and meta‐analyses on the effectiveness of Huperzine A
Nafiseh Ghassab-Abdollahi, Khorshid Mobasseri, Ali Dehghani Ahmadabad, H. Nadrian, M. Mirghafourvand   +4 more
semanticscholar   +1 more source

Synthesis of (±)-desamino huperzine A

Tetrahedron Letters, 2000
The first synthesis of desamino huperzine A 2 is described. Key steps are a double Michael addition into benzoquinone monoketal 4, a regiocontrolled double bond isomerisation and a novel pyridone synthesis involving a Michael addition of a ß-keto ester into acrylonitrile. (C) 2000 Elsevier Science Ltd.
Högenauer, Klemens, Baumann, Karl, Mulzer, Johann   +2 more
openaire   +1 more source

Synthesis of a hybrid analog of the acetylcholinesterase inhibitors huperzine A and huperzine B

Tetrahedron Letters, 2001
Abstract The synthesis of a new hybrid analog of the acetylcholinesterase (AChE) inhibitors huperzine A and B is reported. An intramolecular reductive dicarbonyl coupling was used as a key reaction for constructing the tetracyclic ring system.
V Rajendran, Suo-Bao Rong, Ashima Saxena, Bhupendra P Doctor, Alan P Kozikowski   +4 more
openaire   +1 more source

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate)-based microspheres as a sustained platform for Huperzine A delivery for alzheimer's disease therapy.

International Journal of Biological Macromolecules
Huperzine A (HupA) is used in Alzheimer's disease (AD) therapy for its effective inhibition of acetylcholinesterase (AChE) and enhancement of cholinergic neuronal function. However, direct oral administration and injection of HupA cause side effects like
Daixu Wei, Duanfang Cai, Youguo Tan, Kezhi Liu, Jinwei Dao, Xiang Li, Aikeremujiang Muheremua   +6 more
semanticscholar   +1 more source

Microbial transformation of (−)-Huperzine A

Tetrahedron Letters, 2010
Five products were yielded from the transformation of (−)-Huperzine A (1) by Streptomyces griseus CACC 200300. Their structures were determined as 16-hydroxyl huperzine A (2), 14α-hydroxyl huperzine A (3), huperzine A 8α,15α-epoxide (4), 13N-formyl huperzine A (5), and 13N-acetyl huperzine A (6) on the basis of their chemical and physical data.
Xinyuan Zhang, Jian-hua Zou, Jungui Dai
openaire   +1 more source

Huperzine aggravated neurochemical and volumetric changes induced by D-galactose in the model of neurodegeneration in rats.

Neurochemistry International, 2022
The multimodal MRI and 1H MRS study was designed to provide a structural and neurochemical view of D-galactose induced rat brain degeneration and its treatment with huperzine A. The volume changes were captured using MRI focused on the hippocampal region
Lubomir Melichercik, T. Tvrdík, K. Novakova, M. Nemec, M. Kaliňák, L. Baciak, S. Kašparová   +6 more
semanticscholar   +1 more source

Huperzine a ameliorates sepsis-induced acute lung injury by suppressing inflammation and oxidative stress via α7 nicotinic acetylcholine receptor.

International Immunopharmacology
Sepsis, characterized by high mortality rates, causes over 50 % of acute lung injury (ALI) cases, primarily due to the heightened susceptibility of the lungs during this condition.
Jingqian Su, Kunsen Chen, Xiao Sang, Zhihua Feng, Fen Zhou, Heng Zhao, Shun Wu, Xiaohui Deng, Congfan Lin, Xinrui Lin, Lian Xie, Hui Ye, Qi Chen   +12 more
semanticscholar   +1 more source