Results 191 to 200 of about 5,858 (232)

Asymmetric Total Synthesis and Structure Elucidation of Huperzine H.

Journal of Organic Chemistry, 2022
A first asymmetric total synthesis of huperzine H has been achieved in a 12% overall yield from commercially available (+)-pulegone. The key steps of this synthesis include a highly diastereoselective Mukaiyama-Michael addition reaction of a pyrrole ...
S. Shiomi, Kaewsri Wilailak, Wataru Soutome, H. Takayama, M. Kitajima, H. Ishikawa   +5 more
semanticscholar   +1 more source

Huperzine A protected against ferroptosis via activating PI3K/Akt signaling in lipopolysaccharide induced acute lung injury.

European Journal of Pharmacology
Huperzine A (Hup A), an extract from Huperzia serrata, exerted its anti-inflammation and anti-oxidation effect to protect against neurodegenerative disorders and organ injury.
Jun Shi, Wei Chen, Jiajia Tang, Chunyang Zhang, Man Qi, Xin Zheng, Jiaxin Wang, Qi Liu, Lu Liu, Xuxin Chen, Zhi-Yu Han   +10 more
semanticscholar   +1 more source

Advances in the structural modification of Alzheimer's disease drug - Huperzine A.

Bioorganic chemistry (Print)
Huperzine A is an alkaloid featuring a bicyclo [3.3.1] nonane scaffold with an integrated piperidine ring, which was firstly isolated from Huperzia selago in 1960.
Xiao-Xing Zhu, Jin-bu Xu, Feng Gao, Linxi Wan   +3 more
semanticscholar   +1 more source

Huperzine A, a novel promising acetylcholinesterase inhibitor

NeuroReport, 1996
The effects of huperzine A on memory impairments induced by scopolamine were evaluated using a radial maze task and inhibition of cholinesterase in vitro compared with the effects of E2020 and tacrine. Scopolamine (0.2 mg kg-1) significantly impaired spatial memory in rats. Huperzine A (0.1-0.4 mg kg-1, p.o.), E2020 (0.5-1.0 mg kg-1, p.o.) and tacrine (
D H, Cheng, H, Ren, X C, Tang
openaire   +2 more sources

Development and validation of a highly sensitive UPLC-MS/MS method for the determination of Huperzine A in rat plasma.

Biomedical chromotography
Huperzine A is a reversible and selective cholinesterase inhibitor and has been approved for the treatment of Alzheimer's diseases. In this study, we developed a highly sensitive and specific ulta-high-performance liquid chromatography-tandem mass ...
Ke-xin Zhang, Haizhou Wang
semanticscholar   +1 more source

A total synthesis of (±)-huperzine A

Tetrahedron Letters, 1989
Abstract The first total synthesis of (±)-huperzine A, a new lycopodium alkaloid is described.
Ligang Qian, Ruyun Ji
openaire   +1 more source

Huperzine A from Huperzia species—An ethnopharmacolgical review

Journal of Ethnopharmacology, 2007
Huperzine A (HupA), isolated originally from a traditional Chinese medicine Qiang Ceng Ta, whole plant of Huperzia serrata (Thunb. ex Murray) Trev., a member of the Huperziaceae family, has attracted intense attention since its marked anticholinesterase activity was discovered by Chinese scientists.
Xiaoqiang, Ma, Changheng, Tan, Dayuan, Zhu, David R, Gang, Peigen, Xiao   +4 more
openaire   +2 more sources

Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia.

Life Science, 2020
Chronic intermittent hypoxia (CIH) is a consequence of obstructive sleep apnea (OSA), which increases reactive oxygen species (ROS) generation, resulting in oxidative damage and neurocognitive impairment.
Ji-Ren An, Yashuo Zhao, Li-Fei Luo, Peng Guan, M. Tan, En-Sheng Ji   +5 more
semanticscholar   +1 more source

A Formal Synthesis of (+)-Huperzine A

Tetrahedron, 2000
Abstract A new formal stereoselective synthesis of (+)-Huperzine A (1) was achieved using as a key step a palladium mediated annulation between 2-methylene-1,3-propanediol diacetate and (1R,2S)-2-phenylcyclohexanol derived β-ketoester 2c.
Arnaud Haudrechy, Christophe Chassaing, Claude Riche, Yves Langlois   +3 more
openaire   +1 more source

Research on endophytic fungi for producing huperzine A on a large-scale

Critical reviews in microbiology, 2020
Huperzine A (HupA) is an effective inhibitor of acetylcholinesterase and has attracted great interest as a therapeutic candidate for Alzheimer’s disease.
Xiao Sang, Minhe Yang, Jingqian Su
semanticscholar   +1 more source