Results 201 to 210 of about 5,858 (232)

A combination of [+] and [−]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs

Chemico-Biological Interactions, 2013
The neuropathologic mechanisms after exposure to lethal doses of nerve agent are complex and involve multiple biochemical pathways. Effective treatment requires drugs that can simultaneously protect by reversible binding to the acetylcholinesterase (AChE) and blocking cascades of seizure related brain damage, inflammation, neuronal degeneration as well
Ying, Wang, Yanling, Wei, Samuel, Oguntayo, Bhupendra P, Doctor, Madhusoodana P, Nambiar   +4 more
openaire   +2 more sources

A Convergent Approach to Huperzine A and Analogues.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Seán A, Kelly, Yann, Foricher, John, Mann, Jonathan M, Bentley   +3 more
openaire   +2 more sources

Synthesis of 5-substituted analogues of huperzine A

Bioorganic & Medicinal Chemistry Letters, 2000
Three 5-isosteres of huperzine A (2-4) were first synthesized. The key intermediate 10 was prepared by the reaction of acid 13 with LTA. The compounds 2 and 3 had 50% inhibition by 35 and 47 microM, respectively, which still retained antiacetylcholinesterase activity.
G C, Zhou, D Y, Zhu
openaire   +2 more sources

Mechanism of inhibition of cholinesterases by huperzine A

Biochemical and Biophysical Research Communications, 1992
Huperzine A, an alkaloid isolated from Huperzia serrata was found to reversibly inhibit acetylcholinesterases (EC 3.1.1.7) and butyrylcholinesterases (EC 3.1.1.8) with on- and off-rates that depend on both the type and the source of enzyme. Long-term incubation of high concentrations of purified cholinesterases (1-8 microM) with huperzine A did not ...
Y, Ashani, J O, Peggins, B P, Doctor
openaire   +2 more sources

Synthesis of Huperzine B Through Ring Closing Metathesis.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Ihl Young Choi Lee, Joong Yeoun Hong, Myung Hee Jung, Hyo Won Lee   +3 more
openaire   +1 more source

Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B

Bioorganic & Medicinal Chemistry Letters, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Song, Feng, Yu, Xia, Dongmei, Han, Chunyan, Zheng, Xuchang, He, Xican, Tang, Donglu, Bai   +6 more
openaire   +2 more sources

ChemInform Abstract: Synthesis of a Hybrid Analogue (I) of the Acetylcholinesterase Inhibitors Huperzine A and Huperzine B.

ChemInform, 2001
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
V. Rajendran, Suo‐Bao Rong, Ashima Saxena, Bhupendra P. Doctor, Alan P. Kozikowski   +4 more
openaire   +1 more source

[+]-Huperzine A Protects Against Soman Toxicity in Guinea Pigs

Neurochemical Research, 2011
The chemical warfare nerve agent (CWNA) soman irreversibly inhibits acetylcholinesterase (AChE) causing seizure, neuropathology and neurobehavioral deficits. Pyridostigmine bromide (PB), the currently approved pretreatment for soman, is a reversible AChE inhibitor that does not cross the blood-brain barrier (BBB) to protect against central nervous ...
Ying, Wang, Yanling, Wei, Samuel, Oguntayo, Neil, Jensen, Bhupendra P, Doctor, Madhusoodana P, Nambiar   +5 more
openaire   +2 more sources

Clinical and Preclinical Studies with Huperzine

1991
One of the pharmacological approaches currently employed in the treatment of symptoms of dementia in Alzheimer’s disease (AD) is the administration of acetylcholinesterase (AChE) inhibitors. This strategy is used with the goal of inhibiting acetylcholine degradation in vivo, and hence alleviating the cholinergic deficiency which has been shown to occur
Israel Hanin, Xi Can Tang, Alan P. Kozikowski   +2 more
openaire   +1 more source

Huperzine A

2021
Weaam Ebrahim, Ferhat Can Özkaya, Galal T. Maatooq   +2 more
openaire   +1 more source