Results 11 to 20 of about 21,919 (103)
Role of voltage-gated proton channel (Hv1) in cancer biology
Frontiers in Pharmacology, 2023 The acid-base characteristics of tumor cells and the other elements that compose the tumor microenvironment have been topics of scientific interest in oncological research. There is much evidence confirming that pH conditions are maintained by changes in
J. J. Alvear-Arias +6 more
semanticscholar +1 more source
Antioxidants, 2023 Although the precise mechanisms for neurodegeneration in Parkinson’s disease (PD) are unknown, evidence suggests that neuroinflammation is a critical factor in the pathogenic process. Here, we sought to determine whether the voltage-gated proton channel,
Matthew L. Neal +8 more
semanticscholar +1 more source
The Emerging Role of Microglial Hv1 as a Target for Immunomodulation in Myelin Repair
Aging and Disease, 2023 In the central nervous system (CNS), the myelin sheath ensures efficient interconnection between neurons and contributes to the regulation of the proper function of neuronal networks.
Yingxin Tang +10 more
semanticscholar +1 more source
The Voltage-Gated Hv1 H+ Channel Is Expressed in Tumor-Infiltrating Myeloid-Derived Suppressor Cells
International Journal of Molecular Sciences, 2023 Myeloid-derived suppressor cells (MDSCs) are key determinants of the immunosuppressive microenvironment in tumors. As ion channels play key roles in the physiology/pathophysiology of immune cells, we aimed at studying the ion channel repertoire in tumor ...
Marco Cozzolino +7 more
semanticscholar +1 more source
5-Chloro-2-Guanidinobenzimidazole (ClGBI) Is a Non-Selective Inhibitor of the Human HV1 Channel
Pharmaceuticals, 2023 5-chloro-2-guanidinobenzimidazole (ClGBI), a small-molecule guanidine derivative, is a known effective inhibitor of the voltage-gated proton (H+) channel (HV1, Kd ≈ 26 μM) and is widely used both in ion channel research and functional biological assays ...
T. Szanto +9 more
semanticscholar +1 more source
Use of the Outcome and Session Rating Scales in Clinical Social Work Supervision [PDF]
Journal of Social Work Education and Practice, 2019 This paper explores the use of the Outcome Rating Scale (ORS) and the Session Rating Scale (SRS) in clinical social work supervision. These assessment tools are designed to provide clinicians with direct feedback from clients about the clients’ views on ...
Glenn Stone, Bill Frederick, Judy Gray
doaj
Social Work/Maatskaplike Werk, 2004 The existence of work-related problems such as job stress experienced by employees in the workplace and personal problems such as marital problems, interpersonal problems and emotional stress underlines the importance of psychotherapy by employee ...
Florinda Taute
doaj +1 more source
Biomedicines, 2023 Estrogens enhance cellular mitochondrial activity. The diminution of female hormones during menopause may have an effect on the mitochondrial genome and the expression of mitochondrial proteins.
W. Kwaśniewski +5 more
semanticscholar +1 more source
Reaching the Unreachable: The Promise of Telepsychiatry in India
Columbia Social Work Review, 2015 A 2005 study by the National Commission on Macroeconomics and Health indicated that at least 71 million people in India have a serious mental disorder. Despite this alarming statistic, infrastructure as well as manpower for mental health in the country ...
Amrita Parekh
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Trapping Charge Mechanism in Hv1 Channels (CiHv1)
International Journal of Molecular Sciences, 2023 The majority of voltage-gated ion channels contain a defined voltage-sensing domain and a pore domain composed of highly conserved amino acid residues that confer electrical excitability via electromechanical coupling.
Miguel Fernández +10 more
semanticscholar +1 more source