Results 11 to 20 of about 24,136 (113)

Insights on Small Molecule Binding to the Hv1 Proton Channel from Free Energy Calculations with Molecular Dynamics Simulations

open access: yes, 2020
Hv1 is a voltage-gated proton channel whose main function is to facilitate extrusion of protons from the cell. The development of effective channel blockers for Hv1 can lead to new therapeutics for the treatment of maladies related to Hv1 dysfunction ...
Francesco, Tombola   +6 more
core   +3 more sources

Role of voltage-gated proton channel (Hv1) in cancer biology [PDF]

open access: yes, 2023
The acid-base characteristics of tumor cells and the other elements that compose the tumor microenvironment have been topics of scientific interest in oncological research. There is much evidence confirming that pH conditions are maintained by changes in
Antonio Pena-Pichicoi   +6 more
core   +3 more sources

Gating of the Hv1 proton channel

open access: yes, 2022
Hv1 is a voltage-gated proton channel, which is involved in the regulation of the intracellular pH (pHi) in immune cells. Among the voltage-gated ion channels, Hv1 is unique because it lacks a classical pore domain and its voltage-sensor domain (VSD ...
Schladt, Till Moritz, Schladt, T.
core   +1 more source

The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury [PDF]

open access: yes, 2021
Activation of spinal cord microglia contributes to the development of peripheral nerve injury-induced neuropathic pain. However, the molecular mechanisms underlying microglial function in neuropathic pain are not fully understood.
Gongxiong Wu   +21 more
core   +1 more source

Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives [PDF]

open access: yes, 2014
The voltage-gated proton channel Hv1 plays important roles in proton extrusion, pH homeostasis, and production of reactive oxygen species in a variety of cell types.
Hong, Liang   +2 more
core   +1 more source

Reaching the Unreachable: The Promise of Telepsychiatry in India

open access: yesColumbia Social Work Review, 2015
A 2005 study by the National Commission on Macroeconomics and Health indicated that at least 71 million people in India have a serious mental disorder. Despite this alarming statistic, infrastructure as well as manpower for mental health in the country ...
Amrita Parekh
doaj   +1 more source

Undoing the Damage: Working with LGBT Clients in Post-Conversion Therapy

open access: yesColumbia Social Work Review, 2012
As a mecca of diversity, New York City is one of the epicenters for the lesbian, gay, bisexual, and transgender LGBT community. As such, LGBT identified clients present in New York’s counseling and mental health agencies with a cross section of issues ...
Jessica Horner
doaj   +1 more source

UMNH:Mamm:9960

open access: yes, 2021
UMNH:Mamm:9960 Voucher specimen study ...
UMNH VZ Staff
core  

Trapping Charge Mechanism in Hv1 Channels (CiHv1) [PDF]

open access: yes, 2023
The majority of voltage-gated ion channels contain a defined voltage-sensing domain and a pore domain composed of highly conserved amino acid residues that confer electrical excitability via electromechanical coupling.
Emerson M. Carmona   +21 more
core   +1 more source

Considerazioni sulla cocaina: presentazione ed analisi di una casistica / Considérations sur la cocaïne : présentation et analyse d’une liste de cas / Considerations about cocaine: analysis and presentation of a case-record [PDF]

open access: yesRivista di Criminologia, Vittimologia e Sicurezza, 2012
L’usage de cocaïne représente un danger pour la santé et notre pays a prévu une norme détaillée en la matière, le DPR n° 309/90, modifié suite à un référendum abrogatif en 1993 qui a dépénalisé la détention de drogue pour usage personnel (ce dernier est ...
Massoni Francesco   +5 more
doaj  

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