Results 41 to 50 of about 21,919 (103)

Interior pH Sensing Residue of Human Voltage-Gated Proton Channel Hv1 is Histidine 168

bioRxiv
The molecular mechanisms governing the human voltage-gated proton channel hHv1 remain elusive. Here we used membrane-enabled hybrid-solvent continuous constant pH molecular dynamics (CpHMD) simulations with pH replica exchange to further evaluate the ...
Mingzhe Shen, Yandong Huang, Zhitao Cai, V. Cherny, T. DeCoursey, Jana K. Shen   +5 more
semanticscholar   +1 more source

Identification of a Novel Structural Class of HV1 Inhibitors by Structure-Based Virtual Screening

Journal of Chemical Information and Modeling
The human voltage-gated proton channel, hHV1, is highly expressed in various cell types including macrophages, B lymphocytes, microglia, sperm cells and also in various cancer cells.
Martina Piga, Zoltán Varga, Ádám Fehér, F. Papp, Éva Korpos, Kavya C. Bangera, R. Frlan, J. Ilaš, J. Dernovšek, T. Tomašič, Nace Zidar   +10 more
semanticscholar   +1 more source

Inhibition of the HV1 voltage-gated proton channel compromises the viability of human polarized macrophages in a polarization- and ceramide-dependent manner

Frontiers in Immunology
The human voltage-gated proton channel (HV1) provides an efficient proton extrusion pathway from the cytoplasm contributing to the intracellular pH regulation and the oxidative burst. Although its pharmacological inhibition was previously shown to induce
Tamás Kovács, Bence Cs. Szabo, Rosemary Chandrakanthi Kothalawala, Virag Szekelyhidi, Péter Nagy, Zoltan Varga, G. Panyi, F. Zákány   +7 more
semanticscholar   +1 more source

An essential role for the Hv1 voltage-gated proton channel in Pseudomonas aeruginosa corneal infection

bioRxiv
Assembly of NADPH oxidase 2 (NOX2) proteins in neutrophils plays an essential role in controlling microbial infections by producing high levels of reactive oxygen species (ROS). We reported that neutrophils and NOX2 are required to control P.
Priscila Rodriguez, Serena Abbondante, M. Marshall, J. T. Chau, Jessica Abdelmeseh, J. Nourse, Francesco Tombola, Eric Pearlman   +7 more
semanticscholar   +1 more source

A definição de trabalho social da FITS: Por que revisar? The IFSW social work definition: Why should it be reviewed?

Serviço Social & Sociedade, 2011
O texto que segue trata do debate brasileiro sobre a definição de Serviço Social aprovada pela Federação Internacional de Trabalhadores Sociais - Fits na assembleia de Montreal, Canadá, no ano 2000.
doaj   +1 more source

Deficiency of the microglial Hv1 proton channel attenuates neuronal pyroptosis and inhibits inflammatory reaction after spinal cord injury

Journal of Neuroinflammation, 2020
Background Spinal cord injury (SCI) causes neurological dysfunction with devastating consequences. SCI pathogenesis is accompanied by inflammasome activation and neuronal damage.
Xuefei Li, Zhi-yuan Yu, Wei-feng Zong, Peng Chen, Jia Li, Minghuan Wang, Fengfei Ding, M. Xie, Wei Wang, Xiang Luo   +9 more
semanticscholar   +1 more source

No One is Illegal Between City and Nation

Studies in Social Justice, 2011
By challenging the state's prerogative to distinguish between insiders and outsiders, citizens and non-citizens, political movements by and in support of migrants and refugees are forcing questions about what criteria, if any, can and should be used to ...
Peter Nyers
doaj  

Discovering Jewish Studies Collections in Academic Libraries: A Practical Guide

, 2014
The U.S. colleges and universities offering non-sectarian educational programs in Jewish Studies rely on the support of their academic libraries for research materials and library services.
Taler, Izabella
core  

Deficiency of Hv1 Proton Channel Enhances Macrophage Antigen Presentation and Anti-Tumor Responses in Glioma

bioRxiv
In the tumor microenvironment of glioblastoma, myeloid cells act as a double-edged sword—they are a major cellular component modulating the immune response while presenting a potential therapeutic target.
Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, K. Ayasoufi, E. Goddery, P. Strege, Yushan Wan, Wenjing Zhang, Manling Xie, Arthur Beyder, Aaron J. Johnson, Long-jun Wu   +11 more
semanticscholar   +1 more source

Recensione / Book review [PDF]

Rivista di Criminologia, Vittimologia e Sicurezza, 2015
Lacatena A. P., Resto umano. Storia vera di un uomo che non si è mai sentito donna, Chinaski edizioni, Genova, 2014,
Sicurella Sandra
doaj