Results 81 to 90 of about 21,919 (103)

Knockout of microglial Hv1 proton channel reduces neurotoxic A1 astrocytes and neuronal damage via the ROS/STAT3 pathway after spinal cord injury.

Glia, 2023
Spinal cord injury (SCI) causes severe functional deficits and neuronal damage, accompanied by intense glial activation. The voltage-gated proton channel Hv1, selectively expressed on microglia, is associated with SCI progression.
Ying Li, Yiwen Xie, Ruichao Liu, Ziyue Wang, Pengshan Chen, Minghuan Wang, Zhi-yuan Yu, Wei Wang, Xiang Luo   +8 more
semanticscholar   +1 more source

Microglial reprogramming by Hv1 antagonism protects neurons from inflammatory and glutamate toxicity

Journal of Neurochemistry, 2023
Although the precise mechanisms determining the neurotoxic or neuroprotective activation phenotypes in microglia remain poorly characterized, metabolic changes in these cells appear critical for these processes.
Diego R Hernandez-Espinosa, J. Gale, Mia G. Scrabis, E. Aizenman   +3 more
semanticscholar   +1 more source

Proton Paths in Models of the Hv1 Proton Channel.

Journal of Physical Chemistry B, 2023
The voltage-gated proton channel (Hv1) plays an essential role in numerous biological processes, but a detailed molecular understanding of its function is lacking.
T. Lazaridis
semanticscholar   +1 more source

Amyloid precursor protein and C99 are subunits in human microglial Hv1 channels that enhance current and inflammatory mediator release

Proceedings of the National Academy of Sciences of the United States of America
Significance Microglial-mediated neuroinflammation is strongly implicated in the development and progression of Alzheimer’s disease (AD). Here we demonstrate that human induced pluripotent stem cell (iPSC)-microglia (iMG) employ voltage-gated proton ...

semanticscholar   +1 more source

Deficiency of Microglial Hv1 Protects Against Lipopolysaccharide‐Induced Neuroinflammation via the NF‐κB Signaling Pathway and HIF1α‐Mediated Metabolic Reprogramming

The FASEB Journal
Neuroinflammation plays a pivotal role in the initiation and progression of cognitive impairments. Hv1 channels have been implicated in proton extrusion, microglial activation, and neuroinflammation onset.
Lingbin Sun, Xihua Wang, S. Guan, Ping Zhang, Dongling Chen, Tao Luo   +5 more
semanticscholar   +1 more source

Brain targeted lipid nanoparticles with Hv1 inhibitors alleviate neuroinflammation post-ischemic stroke

Journal of Nanobiotechnology
Ischemic stroke (IS) represents a significant global health burden. Current therapeutic options face problems such as window narrowing and reperfusion injury risk.
Zeyu Yang, Lei Jin, Longxiang Li, Yu Wu, Wenchao Liu, Xin Feng, Liyan Li, Fa Jin, Yiming Bi, Ran Li, Shenquan Guo, Yanan Wang, Boyang Wei, Yanchao Liu, Xifeng Li, Chuanzhi Duan   +15 more
semanticscholar   +1 more source

Modulators of the Human Voltage-Gated Proton Channel Hv1

Pharmaceuticals
The voltage-gated proton channel (Hv1) selectively transports protons (H+) across biological membranes in response to membrane potential changes. Hv1 is assembled as a dimer, and unlike most voltage-gated ion channels, it lacks a traditional central pore
Jesús Borrego, Beáta Mészáros, T. Szanto, Russo Teklu Teshome, Éva Korpos, Zoltán Varga, F. Papp   +6 more
semanticscholar   +1 more source

Therapeutic Modulation of the Nox2–Hv1–ROS Axis by Botulinum Neurotoxin A Confers Protection Against CoCl2-Induced Retinal Hypoxic Injury

International Journal of Molecular Sciences
Neuroinflammation and oxidative stress are key drivers of various ocular diseases. Experimental hypoxia, modeled using cobalt chloride (CoCl2), induces hypoxia-inducible factor 1-alpha (HIF-1α) stabilization, mitochondrial dysfunction, and excessive ...
Hey Jin Lee, Mira Park, Hyun-Ah Shin, Helen Lew   +3 more
semanticscholar   +1 more source

Validation of Hv1 channel functions in BV2 microglial cells using small molecule modulators

Frontiers in Cellular Neuroscience
Microglia are the first responders to insults or damages in the brain where they display both beneficial and detrimental effects. Excessively activated microglia aggravate the secondary damage by producing several proinflammatory mediators. Voltage-gated
Ashutosh Sharma, Nandini B. Kale, Priyanka Yadav, Shivani Yadav, Madhavi Ranawat, Valmik S. Shinde, A. Kshatri   +6 more
semanticscholar   +1 more source

Proton channel Hv1 modulates microglial responses to neurological disorders

Frontiers in Biophysics
Proton channels are transmembrane proteins that enable selective proton (H+) transport. The voltage-gated proton channel Hv1 or HVCN1 is the only one found in mammalian cells, primarily in immune cells, where it facilitates rapid proton extrusion in ...
Maite Stratmann, Caterina Gagliardi, Melania Capasso   +2 more
semanticscholar   +1 more source