Cationic Peptoids for Systemic In Vivo Cartilage‐Targeting
Systemically‐dosed Cy5‐labeled cationic peptoid probe (NlysO)7 (yellow) binds to the cartilage's glycosaminoglycan content in vivo across the entire body of a neonatal mouse imaged by light sheet fluorescence microscopy, revealing fluorescence uptake in generic cartilage as well as the developing and ossifying bones.
Chaonan Zhang+6 more
wiley +1 more source
CXCR1 Depletion in Ly6C+ cDC2 Alleviates Acute Lung Injury via Modulation of Th17/Treg Balance
Pro‐inflammatory Ly6C⁺ cDC2s are identified as key effector cells mediating Cxcr1 signaling, driving the progression of ALI. Ly6C⁺ cDC2s release high levels of Il‐6 and Il‐1β, inducing Th17 differentiation. Cxcr1 deficiency reduces Il‐6 and Il‐1β production from Ly6C⁺ cDC2s through suppressing MEK1/ERK /NF‐κB signaling, thereby shifts naïve T cells ...
Shenghui Li+8 more
wiley +1 more source
Diversity of Lecidea (Lecideaceae, Ascomycota) species revealed by molecular data and morphological characters [PDF]
The diversity of lichens, especially crustose species, in continental Antarctica is still poorly known. To overcome difficulties with the morphology based species delimitations in these groups, we employed molecular data (nuclear ITS and mitochondrial ...
Brunauer, Georg+4 more
core +4 more sources
A new species of Anastrepha from Amazonia : with redescriptions of A. caudata Stone and A. hendeliana Lima (Diptera: Tephritidae) [PDF]
Three species of Anastrepha from upper Amazonia are described or redescribed and illustrated. They are considered closely related and are placed in the A. caudata species group. Anastrepha caudata Stone 1942 is redescribed based on the holotype, the only
Caraballo, Josefina, Norrbom, Allen L.
core
Five new species of the genera Heerz Marsh, Lissopsius Marsh and Ondigus Braet, Barbalho and van Achterberg (Braconidae, Doryctinae) from the Chamela-Cuixmala biosphere reserve in Jalisco, Mexico [PDF]
Five new species belonging to the poorly known Neotropical doryctine parasitoid wasps genera Heerz Marsh (H. ecmahla sp. n. and H. macrophthalma sp. n.), Lissopsius Marsh (L. pacificus sp. n. and L. jalisciensis sp.
Ceccarelli, Fadia Sara+3 more
core +4 more sources
This article examines the central role of RIPK1 in the pathogenesis of sepsis‐induced lung injury. It elucidates how RIPK1 initiates an inflammatory cascade by activating JAK1‐STAT3 signaling, leading to CXCL1‐mediated neutrophil infiltration. Importantly, it demonstrates that pharmacological inhibition of RIPK1 effectively attenuates inflammation and ...
Hao Sun+15 more
wiley +1 more source
Histological Findings Upon Patients Undergoing Revision Surgery after AMIC of the Talus
Category: Ankle Arthritis Introduction/Purpose: Failure after AMIC (autologous matrix-induced chondroplasty) of the talus is relatively rare and ranges between 2-6%.
Fabian Krause MD+2 more
doaj +1 more source
An autopsy study of a familial oculopharyngeal muscular dystrophy (OPMD) with distal spread and neurogenic involvement [PDF]
An 81-year-old man from a family with a history of oculopharyngeal muscular dystrophy (OPMD) involving 6 members over 4 generations is described. The patient first noted drooping of his eyelids at the age of 65.
Aarli+49 more
core +1 more source
Lipopolysaccharide (LPS) stimulates the production of succinic acid in lung tissue, which promotes macrophages endocytosis and the formation of multivesicular bodies (MVBs). These MVBs release profibrotic extracellular vesicles (EVs), facilitating the transfer of integrin beta1 (ITGβ1) transfer and subsequently activating fibroblasts, thereby ...
Wenyu Yang+10 more
wiley +1 more source
Background Little is known about the relationship between splenic arteriolar hyaline and cause of death. The purpose of this retrospective study was to evaluate the clinicopathological significance of splenic arteriolar hyaline in autopsy cases and ...
Kotani Hirokazu+6 more
doaj +1 more source