Results 221 to 230 of about 82,581 (251)

Metabolic dysfunction-associated steatotic liver disease and immune checkpoint inhibitor response in gastrointestinal liver metastases: current evidence and future directions. [PDF]

Front Nutr
Guo S, Liu B, Li H, Yu Y, Xu J.
europepmc   +1 more source

Molecular Basis of Glia-ECM Interplay in Central Nervous System Homeostasis and Plasticity. [PDF]

Cells
Wang L, Ma X, Zeng Q, Liu M, Yue Z, Hu R.   +5 more
europepmc   +1 more source

Intracellular Hyaluronan: Importance for Cellular Functions

Seminars in Cancer Biology, 2020
Hyaluronan-rich matrices are abundant in ECM and are involved in biological processes, such as cell growth and migration. Hyaluronan is synthesized by the hyaluronan synthase family of enzymes, HAS1, HAS2 and HAS3; the HAS1 and HAS3 genes give rise to ...
Theodoros T Karalis, Paraskevi Heldin, Spyros S Skandalis   +2 more
exaly   +3 more sources

Involvement of hyaluronan and CD44 in cancer and viral infections.

Cellular Signalling, 2019
Hyaluronan and its major receptor CD44 are ubiquitously distributed. They have important structural as well as signaling roles, regulating tissue homeostasis, and their expression levels are tightly regulated.
P. Heldin, Constantinos Kolliopoulos, Chun-Yu Lin, C. Heldin   +3 more
semanticscholar   +2 more sources

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Hyaluronan: From Extracellular Glue to Pericellular Cue

Nature Reviews Cancer, 2004
Bryan P Toole
exaly   +2 more sources

Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production.

Matrix Biology, 2018
The tightly regulated biosynthesis and catabolism of the glycosaminoglycan hyaluronan, as well as its role in organizing tissues and cell signaling, is crucial for the homeostasis of tissues.
P. Heldin, Chun-Yu Lin, Constantinos Kolliopoulos, Yen-Hsu Chen, S. Skandalis   +4 more
semanticscholar   +2 more sources

Hyaluronan: Polysaccharide Chaos to Protein Organisation

Current Opinion in Structural Biology, 2001
Molecular dynamics simulations of hyaluronan have revealed the inherent flexibility of this glycosaminoglycan in solution. Crystal structures of hyaluronan-digesting enzymes have provided the first direct insights into the molecular basis of hyaluronan ...
Anthony J Day, J K Sheehan
exaly   +2 more sources

Revisiting the hallmarks of cancer: the role of hyaluronan.

Seminars in Cancer Biology, 2020
Extracellular matrix (ECM) is a complex network of macromolecules such as proteoglycans (PGs), glycosaminoglycans (GAGs) and fibrous proteins present within all tissues and organs.
I. Caon, B. Bartolini, Arianna Parnigoni, E. Caravà, P. Moretto, M. Viola, E. Karousou, D. Vigetti, A. Passi   +8 more
semanticscholar   +1 more source

Hyaluronan-CD44 axis orchestrates cancer stem cell functions.

Cellular Signalling, 2019
The prominent role of CD44 in tumor cell signaling together with its establishment as a cancer stem cell (CSC) marker for various tumor entities imply a key role for CD44 in CSC functional properties.
S. Skandalis, Theodoros Karalis, A. Chatzopoulos, Nikos Karamanos   +3 more
semanticscholar   +1 more source

Hyaluronan in the lymphatics: The key role of the hyaluronan receptor LYVE-1 in leucocyte trafficking.

Matrix Biology, 2018
LYVE-1, a close relative of the leucocyte receptor, CD44, is the main receptor for hyaluronan (HA) in lymphatic vessel endothelium and a widely used marker for distinguishing between blood and lymphatic vessels.
D. Jackson
semanticscholar   +1 more source