Results 81 to 90 of about 67,369 (315)

Deficiency in mouse hyaluronidase 2: a new mechanism of chronic thrombotic microangiopathy

Haematologica, 2015
Hyaluronan is a major component of the extracellular matrix and glycocalyx. Its main somatic degrading enzymes are hyaluronidases 1 and 2, neither of which is active in the bloodstream. We generated hyaluronidase 2-deficient mice.
Cécile Onclinx, Sophie Dogne, Laurence Jadin, Fabienne Andris, Christian Grandfils, François Jouret, François Mullier, Bruno Flamion   +7 more
doaj   +1 more source

Hyaluronic acid alters vessel behavior in CXCL12-treated HUVECs [PDF]

, 2018
Hyaluronic acid (HA) is a key component of the extracellular matrix known for absorbing water, swelling, and altering solid stress of tumors. HA’s anionic behavior may provide important biochemical effects toward tumor progression as well.
Seibel, Alex J.
core  

Irgm1 Improves Postinfarction Cardiac Repair by Promoting Neutrophil Clearance and Efferocytosis

Advanced Science, EarlyView.
The Irgm1‐PDIA3 axis enhances post‐infarction cardiac repair by accelerating neutrophil clearance and facilitating efferocytosis. Irgm1 holds potential as a prognostic biomarker in MI, and LOC14 may represent a therapeutic option to improve cardiac repair, especially in cases of Irgm1 deficiency.
Zeng Wang, Lai Wei, Mingyang Wang, Shanjie Wang, Lili Xiu, Jiaxiang Sun, Rongzhe Lu, Yige Liu, Jiaxin Wang, Fengyi Liu, Weike Liu, Bo Yu, Yong Sun, Xueqin Gao, Shaohong Fang   +14 more
wiley   +1 more source

Experimental Study of The Pharmacokinetics of Cefotaxime with Joint Administration of Drugs with Hyaluronidase Activity

Антибиотики и Химиотерапия, 2020
It Is shown that the preliminary administration of drugs that promote the flow of antibiotics into the lymphatic system increases the clinical effectiveness of treatment.
M. V. Zhuravleva, G. V. Kukushkin, L. P. Sviridkina, D. E. Yurov, T. R. Kameneva   +4 more
doaj   +1 more source

Transcriptomic analysis of Ascaris suum larvae during their hepatopulmonary migration [PDF]

, 2012
Common roundworms are important intestinal nematodes of man (Ascaris lumbricoides) and pig (Ascaris suum). During the first stages of the infection, the larvae of these parasites undergo a hepatopulmonary migration.
Gasser, Robin, Geldhof, Peter, Jex, Aaron, Vlaminck, Johnny, Wang, Tao   +4 more
core   +1 more source

Photoprotection and Antiaging Activity of Extracts from Honeybush (Cyclopia sp.)—In Vitro Wound Healing and Inhibition of the Skin Extracellular Matrix Enzymes: Tyrosinase, Collagenase, Elastase and Hyaluronidase [PDF]

, 2023
Anna Hering, Justyna Stefanowicz‐Hajduk, Magdalena Gucwa, Bartosz Wielgomas, J. Renata Ochocka   +4 more
openalex   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Considerations for Proper Use of Hyaluronidase in the Management of Hyaluronic Acid Fillers

Plastic and Reconstructive Surgery, Global Open
Summary:. Effective management of complications from hyaluronic acid (HA) fillers is crucial in aesthetic medicine. This article examined the role of hyaluronidase in addressing adverse effects associated with HA fillers, such as nodules, vascular ...
Kyu-Ho Yi, MD, PhD, Jovian Wan, MBChB, Song Eun Yoon, MD   +2 more
doaj   +1 more source

Involvement of hyaluronidases in colorectal cancer [PDF]

, 2010
Background Hyaluronidases belong to a class of enzymes that degrade, predominantly, hyaluronan. These enzymes are known to be involved in physiological and pathological processes, such as tumor growth, infiltration and angiogenesis, but their
Helen Bouga, Isidoros Tsouros, Dimitrios Bounias, Dora Kyriakopoulou, Michael S Stavropoulos, Nikoletta Papageorgakopoulou, Dimitrios A Theocharis, Demitrios H Vynios   +7 more
core   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source