Results 31 to 40 of about 7,332,950 (253)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution? [PDF]

, 2009
The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based
Anja Ehrhardt, Nadine Müther, Ehrhardt, Anja, Nadja Noske, Müther, Nadine, Noske, Nadja, Nadine Müther   +6 more
core   +1 more source

MXene-driven nanoscale field-effect junction for advanced 4-terminal perovskite/silicon tandem solar panels

Nature Communications
The commercialization of perovskite/silicon tandem solar cells hinges on achieving high efficiency and stability while maintaining scalability. This study demonstrates an original approach for inducing the formation of a field effect junction within the ...
Antonio Agresti, Sara Pescetelli, George Viskadouros, Anna Pazniak, Enrico Leonardi, Alessia Di Vito, Peyman Amiri, Matthias Auf Der Maur, Francesca Menchini, Silvano Del Gobbo, Francesco Di Giacomo, Giuseppe Bengasi, Carmelo Connelli, Luca Sorbello, Marina Foti, Francesco Bonaccorso, Emmanuel Kymakis, Aldo Di Carlo   +17 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Strategies of eradicating glioma cells : a multi-scale mathematical model with miR-451-AMPK-mTOR control [PDF]

, 2015
The cellular dispersion and therapeutic control of glioblastoma, the most aggressive type of primary brain cancer, depends critically on the migration patterns after surgery and intracellular responses of the individual cancer cells in response to ...
Gibin Powathil, Trucu Dumitru, Kang Hyunji, Kim Hyeongi, Chaplain Mark, Lawler Sean, Mark Chaplain, Gibin Powathil (687047), Powathil, Gibin, Hyeongi Kim, Trucu, Dumitru, Kim, Hyeongi, Dumitru Trucu, Sean Lawler (191146), Kim, Yangjin, Hyunji Kang, Hyeongi Kim (687050), Yangjin Kim, Lawler, Sean, Kim Yangjin, Sean Lawler, Kang, Hyunji, Hyunji Kang (687048), Trucu, Dumitru; id_orcid, Dumitru Trucu (687049), Mark Chaplain (249544), Powathil Gibin, Chaplain, Mark, Yangjin Kim (191134), Chaplain, Mark; id_orcid   +29 more
core   +1 more source

Enhancing Charge Transfer in Perovskite‐Inspired Silver Iodobismuthate‐Based Solar Cells via Cesium Iodide Interlayer

Advanced Energy & Sustainability Research
Ag3BiI6 (ABI) is one of the most widely explored lead‐free perovskite‐inspired materials for eco‐friendly solar cell applications. However, despite the intense research efforts, the photovoltaic performance of ABI‐based devices remains very modest ...
Basheer Al‐Anesi, Vipinraj Sugathan, Joshua K. G. Karlsson, Amit Tewari, Roshan Nasare, Paavo Mäkinen, Debjit Manna, Matti Mäntysalo, Paola Vivo   +8 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Lead‐Free Sb–Bi Perovskite‐Inspired Memristors: Compositional Control of Vacancy Migration for Neuromorphic Computing

Small Structures
Neuromorphic hardware demands device elements that integrate low‐voltage analog memory with neuron‐like dynamics, all integrated into a sustainable materials platform.
Ramesh Kumar, Noora Lamminen, Aman Ghadge, Monojit Bag, G. Krishnamurthy Grandhi, Paola Vivo   +5 more
doaj   +1 more source

Is Doping of Spiro-OMeTAD a Requirement for Efficient and Stable Perovskite Indoor Photovoltaics?

Advanced Devices & Instrumentation
Lead halide perovskite (LHP) photovoltaics deliver high voltages even under low-light illumination intensities, thus emerging as a promising indoor photovoltaic (IPV) technology.
Sami Toikkonen, G. Krishnamurthy Grandhi, Shaoyang Wang, Bora Baydin, Basheer Al-Anesi, L. Krishnan Jagadamma, Paola Vivo   +6 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source