Results 41 to 50 of about 100,276 (216)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Spectrometric analysis of intentionally stained hybrid and nanohybrid composites – An In vitro study

Journal of International Clinical Dental Research Organization, 2019
Background: This study aims to investigate the effects of different staining solutions on the color stability of hybrid composites and nanohybrid composites.
Babita Meena, Mukesh Hasija, K K Wadhwani, Deepti Wadhwa   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A Novel Method of Light Weighting Aluminium Using Magnesium Syntactic Composite Core

Crystals, 2020
In this study, hybrid composite consisting of aluminium (Al) shell and magnesium/glass microballoon (Mg-20 wt.% GMB) syntactic composite core was fabricated in a shell-core pattern by combining powder metallurgy and disintegrated melt deposition (DMD ...
Penchal Reddy Matli, Joshua Goh Yong Sheng, Gururaj Parande, Vyasaraj Manakari, Beng Wah Chua, Stephen Chee Khuen Wong, Manoj Gupta   +6 more
doaj   +1 more source

Mechanical and Acoustic properties of Bagasse – Coconut Coir based Hybrid Reinforced Composites

Journal of Natural Fibers, 2022
In this paper, a hybrid composite is developed from natural fibers of bagasse and coconut coir. The mechanical and acoustic properties of the hybrid composites are investigated.
M.K. Marichelvam, K. Kandakodeeswaran, M. Geetha   +2 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Development of Guinea Corn Husk-Cow Hair Hybrid Fibre Reinforced Cement Composite

Journal of Building Materials and Structures, 2021
This research work presents the application of guinea corn husk (GCH) and cow hair (CH) fibres as reinforcement in cement composite. The influence of the hybrid fibre volume on the flexural performance of the composite has been studied experimentally ...
Jonathan Alomaja, Alao Jimoh, Uwemedimo Wilson, Oluwatoyin Joseph, Monsuru Akinleye, Joseph Adeleke   +5 more
doaj  

Studies on Mechanical Properties of Kevlar/Napier Grass Fibers Reinforced with Polymer Matrix Hybrid Composite

Advances in Materials Science and Engineering, 2021
A percentage of natural fibers is used for developing a composite, the materials are quite increasing in recent trends, and they can be a potential replacement of synthetic fibers in the reinforcement phase of hybrid composite.
R. Ganesamoorthy, R. Meenakshi Reddy, T. Raja, Pradeep Kumar Panda, Sneha H. Dhoria, Omaima Nasif, Saleh Alfarraj, Velu Manikandan, I. Jenish   +8 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source