Results 41 to 50 of about 28,580 (259)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Integration of virtual platforms for enhanced conference experience: Data-based evidence from the Society of Interdisciplinary Placebo Studies 2021 conference

Frontiers in Communication, 2022
BackgroundThe Society of Interdisciplinary Placebo Studies (SIPS) was one of many organizations that hosted a virtual scientific conference in response to the COVID-19 pandemic restrictions.
Jessica Cornell, Ariana Taj, John Sivinski, Margaret Yin, Parth Bhatia, Desai Oula, Desai Oula, Sophia Fatschel, Sophia Fatschel, Patricia Franklin, Jason Noel, Luana Colloca, Luana Colloca, Chamindi Seneviratne, Chamindi Seneviratne   +14 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

READINESS OF UNIVERSITY LIBRARIES FOR ONLINE COMMUNICATION AND INTERACTION: UNILIBNSD-2020 INTERNATIONAL CONFERENCE

University Library at a New Stage of Social Communications Development, 2020
A new (5th) issue of the journal “University Library at a New Stage of Social Communications Development. Conference Proceedings” is presented. Full-format papers were selected, reviewed and recommended by the members of the international editorial board
Tetiana O. KOLESNYKOVA
doaj   +1 more source

Tłumaczenie symultaniczne mowy noblowskiej w dydaktyce przekładu konferencyjnego

Między Oryginałem a Przekładem, 2021
Simultaneous Interpreting of a Nobel Lecture in Conference Interpreter Training Simultaneous interpreting with text is a hybrid mode combining simultaneous with sight translation.
Agnieszka Biernacka
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Practice Preferences using Resuscitative Endovascular Balloon Occlusion of the Aorta for Traumatic Injury Before and After the 2017 EndoVascular and Hybrid Trauma and Bleeding Management Symposium

Journal of Endovascular Resuscitation and Trauma Management, 2023
Background: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a technique to aid in resuscitative eff orts for hemorrhagic shock.
Erik DeSoucy, Melissa Loja, Anders J Davidson, Edwin R Faulconer, Rachel M Russo, Meryl A Simon, Joseph J DuBose   +6 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Conference Tourism: Exploring Economic Prospects in the Post-COVID-19 Era—Qualitative Research on Greek Hotel Executives

Businesses, 2023
As is widely known, the COVID-19 pandemic has affected tourism and related activities globally. Due to the restrictive measures implemented for gatherings and movements in order to limit the spread of the virus, conferences and conference tourism ...
Pelagia Moloni, Theodore Metaxas
doaj   +1 more source

A Lightweight Procedural Layer for Hybrid Experimental–Computational Workflows in Materials Science

Advanced Engineering Materials, EarlyView.
We unveil a prototype hybrid‐workflow framework that fuses automatedcomputation with hands‐on experiments. Built atop pyiron, a lightweight, parameterized layer translates procedure descriptions into executable manual steps, syncing instrument settings, human interventions, and data capture in real‐time today.
Steffen Brinckmann, Sarath Menon, Raphael Röske, Johannes Steinhülb, Michael Selzer, Jan Janssen, Tilmann Hickel, Ruth Schwaiger, Jörg Neugebauer   +8 more
wiley   +1 more source