Results 161 to 170 of about 170,545 (305)

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

Advanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao, Hong‐Yi Zhao, Chengyi Li, Hanning Wen, Fang Ke, Qiuxia Li, Miao He, Bo Wen, Zhongwei Liu, Kai Sun, Wei Gao, Duxin Sun   +11 more
wiley   +1 more source

Powertrain configuration design for two mode power split hybrid electric vehicle. [PDF]

Sci Rep
Ke T, Nie L, Kecskeméthy A.
europepmc   +1 more source

Integrated Optimization of Mars Hybrid Solar-Electric/Chemical Propulsion Trajectories [PDF]

NASAs Human Exploration and Operation Mission Directorate is developing a reusable hybrid transportation architecture in which both chemical and solar-electric propulsion systems are used to deliver crew and cargo to the Martian sphere of influence.
Chai, Patrick R., Merrill, Raymond G., Qu, Min   +2 more
core   +1 more source

Lithiation‐Driven LiCrSe2 Shell Growth on Metallic CrSe2 Core Governs the Plateau–Slope Behavior

Advanced Science, EarlyView.
Layered CrSe2 is investigated as a lithium‐ion battery cathode combining fast Li+ diffusion and structural reversibility. Calculations and experiments reveal a single topotactic intercalation process with a characteristic plateau–slope profile governed by lithiation‐induced conductivity changes. A core‐shell lithiation evolution underpins its high‐rate
Weihao Li, Johannes Döhn, Xiao Han, Licheng Zhang, Dave M. Pickup, Xiong Xiao, Yidong Miao, Arun Kumar Samuel, Emily R. Draper, Alan V. Chadwick, Stephen Sproules, Stephen Cottrell, Alan J. Drew, Changhua An, Axel Groß, Alexey Y. Ganin   +15 more
wiley   +1 more source

A 31 L multilevel inverter topology with less switching devices for hybrid electric vehicle applications. [PDF]

Sci Rep
Saravanan K, Sivasubramanian M, Gopinath NP, Kumarasamy K, Azhagumurugan R.   +4 more
europepmc   +1 more source

Fuel-Cell-Powered Vehicle with Hybrid Power Management [PDF]

Figure 1 depicts a hybrid electric utility vehicle that is powered by hydrogenburning proton-exchange-membrane (PEM) fuel cells operating in conjunction with a metal hydride hydrogen-storage unit.
Eichenberg, Dennis J.
core   +1 more source

Tetrahedral DNA Nanostructure‐Based Biomimetic Nanovesicles Attenuate Sepsis‐Associated ARDS by Suppressing Glycolysis via the BMAL1/PFKFB3 Axis

Advanced Science, EarlyView.
Upon inhalation, RM@TNT could persist long‐term in the diseased lungs, while undergoing disintegration to release TNT specifically within the ROS‐rich pathological microenvironments of SA‐ARDS. The released TNT was then precisely delivered to AMs via Tuftsin, where it released Nob intracellularly to activate BMAL1 expression, thus inhibiting AM ...
Yunlong Zhang, Bin Li, Zhijin Fan, Yan Yan, Fei Ma, Changting He, Shiping Liu, Mingliang Pan, Zhou Pan, Huijuan Wang, Xinting Fu, Jiamei Wang, Yue Jia, Qin Gu, Duo Jiang, Xueting Liu, Bohua Ren, Qinqin Wang, Yuehua Hei, Han Duan, Yanqiu Wu, Zihui Wei, Liying Zhan, Yuhui Liao   +23 more
wiley   +1 more source

Machine learning optimization for hybrid electric vehicle charging in renewable microgrids. [PDF]

Sci Rep
Hassan M.
europepmc   +1 more source

Personal Rotorcraft Design and Performance with Electric Hybridization [PDF]

Recent and projected improvements for more or all-electric aviation propulsion systems can enable greater personal mobility, while also reducing environmental impact (noise and emissions).
Snyder, Christopher A.
core   +1 more source

G4‐Ligand‐Directed PROTACs Unveil DR1 as a Novel Ligand‐Co‐Binding G4‐Protein and Reshape G4‐Dependent Transcription

Advanced Science, EarlyView.
G4‐binding proteins (G4BPs) that specifically co‐bind G4s in the presence of small‐molecule ligands represent a critical but unexplored class of proteins. We introduce G4‐Ligand‐Directed PROTACs (G4L‐TACs), a chemical platform that couples G4 ligands (PDS) to E3 recruiters to selectively degrade these ligand‐co‐binding G4BPs.
Mao‐Lin Li, Shu‐Min Xu, Xin‐Chen Jiang, Le‐Tian Dai, Yu‐Tao Hu, Kai‐Bo Wang, Jia‐Heng Tan, Zhi‐Shu Huang, Shuo‐Bin Chen   +8 more
wiley   +1 more source