Results 151 to 160 of about 31,093 (304)

Mechanically Triggered DNA Nanovehicles for Targeted Dual‐Drug Cancer Therapy

Advanced Science, EarlyView.
A mechanically triggered DNA nanovehicle is introduced that co‐releases two anticancer drugs in response to integrin‐mediated cellular forces. Cholesterol‐anchored DNA assemblies undergo force‐induced unfolding at cell–cell junctions, enabling selective, localized dual‐drug activation in cancer cells while minimizing off‐target toxicity in low‐tension ...
Murali Mohana Rao Singuru, Priyanka Bhattacharyya, Mingxu You   +2 more
wiley   +1 more source

Optimal subsidizing policy to promote electric vehicles in Hong Kong

, 2003
In this paper, we propose a framework to optimize the subsidizing policy by taking into account all the lifecycle costs and the environmental benefits of electric vehicles.
Wong, YS, Chau, KT, Chan, CC
core  

Energy management strategy for hybrid electric vehicles based on adaptive equivalent consumption minimization strategy and mode switching with variable thresholds. [PDF]

Sci Prog, 2020
Li Y, Jiao X.
europepmc   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

Self‐Powered Bearing Sensing and Real‐Time Fault Diagnosis Enabled by Non‐Invasive Triboelectric Sensors and Edge AI Acceleration

Advanced Science, EarlyView.
This study achieves the synergistic integration of self‐powered sensing and edge AI acceleration to establish a real‐time fault diagnosis system. The proposed TENG‐based self‐powered bearing sensor (NSE‐TBS) and FPGA‐accelerated edge AI framework fundamentally break through the inherent limitations of conventional monitoring systems, including complex ...
Kehui Zhu, Zhongheng Liu, Xinming Li, Jinrui Zhang, Meng Li, Yiming Guo, Lihua Han, Yanxue Wang   +7 more
wiley   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Efficiency of super capacitor banks used in regenerative breaking in hybrid electric vehicles

, 2009
The aim of this project was to build a supercapacitor bank, dc to dc converter, and testing rig to perform efficiency testing for various configurations of the super capacitor bank against various hybrid electric vehicle regenerative braking profiles.
Napier, David
core  

Physics‐Informed Machine Learning for Sustainable Alloy Design: Toward a Recyclable Unified Q&P Steel

Advanced Science, EarlyView.
A physics‐informed property‐bridging framework links high‐throughput hardness screening to tensile performance in quenching and partitioning steels. By transferring metallurgically guided representations across properties, a single alloy composition is designed to achieve multiple strength grades through heat‐treatment tuning alone, offering a ...
Xiaolu Wei, Yong Li, Chenchong Wang, Lingyu Wang, Xiang Song, Keming Mao, Yu Zhang, Wei Xu   +7 more
wiley   +1 more source

Hydrothermal Embedding of Pd Single Atoms Into SnO2 for Efficient CO Oxidation

Advanced Science, EarlyView.
By applying hydrothermal regulation to SnO2‐supported PdO, we achieve atomic dispersion of Pd into the SnO2 lattice, which activates the lattice oxygen neighboring Pd atoms to generate oxygen vacancies and facilitates subsequent O2 activation, thereby promoting CO oxidation to proceed via a low‐energy‐barrier MvK pathway while avoiding CO poisoning ...
Yingsheng An, Min Xiao, Mengyuan Zhang, Yao Lv, Yanwei Sun, Zhi Liu, Wenbo Pei, Hao Guo, Guangyan Xu, Yong Yan, Sheng Dai, Yunbo Yu, Hong He   +12 more
wiley   +1 more source

Comparative Analysis of Real-Driving Emission Characteristics of Euro 7 Hybrid Electric Vehicles at Varied Ambient Temperatures. [PDF]

ACS Omega
Shi L, Qiu J, Cui S, Yang Y, Ye L, Jin H, Xu X.   +6 more
europepmc   +1 more source