Results 161 to 170 of about 49,201 (297)

Allelic biases in sperm from males that were non-hybrid or hybrid within a lineage versus from males that were hybrids across lineages.

, 2013
Entries in the table are the ratios of peak heights for the two alleles segregating at the locus in DNA from sperm, standardized against the ratio of peak heights from zygotic DNA (fin clips from the same males). Larger numbers signify greater deviations
Richard Borowsky (375425), Dana Cohen (306366)   +1 more
core   +1 more source

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, EarlyView.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

"Leiomyomatoid angiomatous neuroendocrine tumor" (LANT) of the pituitary reflects idiosyncratic angiogenesis in adenomas of the gonadotroph cell lineage.

, 2013
Based on a single-case observation, the descriptive label "leiomyomatoid angiomatous neuroendocrine tumor" (LANT) has been tentatively applied to what was perceived as a possible novel type of dual-lineage pituitary neoplasm with biphasic architecture ...
Birrer, Michèle Andrea, Kappeler, Andreas, Schürch, Christian, Estella, Isabelle, Hewer, Ekkehard, Vajtai, Istvan   +5 more
core   +1 more source

High-Risk Lineages of Hybrid Plasmids Carrying Virulence and Carbapenemase Genes

Antibiotics
Background/Objectives: Carbapenem-resistant Enterobacterales (CRE) are a global health threat due to their high morbidity and mortality rates and limited treatment options. This study examines the plasmid-mediated transmission of virulence and antibiotic resistance determinants in carbapenem-resistant Klebsiella pneumoniae (Kpn) and Escherichia coli (E.
Valeria V. Shapovalova, Polina S. Chulkova, Vladimir A. Ageevets, Varvara Nurmukanova, Irina V. Verentsova, Asya A. Girina, Irina N. Protasova, Victoria S. Bezbido, Victor I. Sergevnin, Irina V. Feldblum, Larisa G. Kudryavtseva, Sergey N. Sharafan, Vladislav V. Semerikov, Marina L. Babushkina, Inna R. Valiullina, Nikita S. Chumarev, Guzel S. Isaeva, Natalya A. Belyanina, Irina U. Shirokova, Tatiana M. Mrugova, Elena I. Belkova, Svetlana D. Artemuk, Aleksandra A. Meltser, Marina V. Smirnova, Tatyana N. Akkonen, Nataliya A. Golovshchikova, Oleg V. Goloshchapov, Alexey B. Chukhlovin, Lubov N. Popenko, Elena Y. Zenevich, Aleksandr A. Vlasov, Galina V. Mitroshina, Marina S. Bordacheva, Irina V. Ageevets, Ofeliia S. Sulian, Alisa A. Avdeeva, Vladimir V. Gostev, Irina A. Tsvetkova, Maria A. Yakunina, Ekaterina U. Vasileva, Alina D. Matsvay, Dmitry I. Danilov, Yulia A. Savochkina, German A. Shipulin, Sergey V. Sidorenko   +44 more
openaire   +3 more sources

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons

, 2011
SummarySeveral recent studies have showed that mouse and human fibroblasts can be directly reprogrammed into induced neuronal (iN) cells, bypassing a pluripotent intermediate state.
Thomas C. Südhof, Marius Wernig, Wernig, Marius, Marro, Samuele, Chang, Howard Y., Miao-Chih Tsai, Yang, Nan, Howard Y. Chang, Südhof, Thomas C., Pang, Zhiping P., Samuele Marro, Qu, Kun, Zhiping P. Pang, Tsai, Miao-Chih, Nan Yang, Kun Qu   +15 more
core   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

A CD24+CD271+ melanoma cancer stem cell possesses hybrid characteristics of its single marker counterparts and promotes invasion and therapeutic resistance

BMC Biology
Background An important role for phenotype switching has been demonstrated in metastasis and therapeutic resistance of both melanoma and epithelial tumours.
Olivia Knowles, Patricio Doldan, Isabella Hillier-Richardson, Sophia Lunetto, Stephanie Lunt, Gehad Youssef, Luke Gammon, Ian C. Mackenzie, Michael P. Philpott, Hasan Rizvi, Daniele Bergamaschi, Catherine A. Harwood, Adrian Biddle   +12 more
doaj   +1 more source