Results 31 to 40 of about 1,605,522 (301)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

A Numerical–Experimental Approach for Multi‐Matrix Fiber‐Reinforced Plastics Characterization Using Finite Element Model Updating

Advanced Engineering Materials, EarlyView.
A numerical–experimental framework is developed for characterizing multi‐matrix fiber‐reinforced polymers (MM‐FRPs) combining epoxy and polyurethane matrices. Harmonic bending tests are integrated with finite element model updating (FEMU) to simultaneously identify elastic and viscoelastic material parameters.
Rodrigo M. Dartora, Tales V. Lisbôa, Axel Spickenheuer, Rogério J. Marczak, Jakson M. Vassoler   +4 more
wiley   +1 more source

3D‐Printed Titanium Gyroid Scaffold Structure Integrated With Tough Hybrid Materials for Cartilage Replacement

Advanced Engineering Materials, EarlyView.
This study proposes a potential device design for joint cartilage replacement. Silica‐polytetrahydrofuran (SiO2‐PolyTHF) hybrids with customizable mechanical properties were developed to mimic the characteristics of a natural meniscus. These were synthesized through a two‐pot sol–gel hybrid process.
Yu‐Chien Lin, Gloria R. Young, Francesca Tallia, Reece N. Oosterbeek, Shaaz Ghouse, Edward Spiers, Nupur Kohli, Tom Briggs, Marc Masen, Siwei Li, Ren‐Jei Chung, Jonathan R. T. Jeffers, Julian R. Jones   +12 more
wiley   +1 more source

Studies on integrated nutrient requirement of hybrid maize (Zea mays L.) under irrigated conditions

Madras Agricultural Journal, 2005
Field experiments were conducted during 2001 and 2002 at Tamil Nadu Agricultural University, Regional Research Station, Paiyur, to study the influence of integrated use of soil application of inorganic and organic nutrients and foliar feeding of major ...
P.PARASURAMAN
doaj   +1 more source

Bio‐Inspired Artificial Ionic Mechanoreceptor

Advanced Functional Materials, EarlyView.
A skin‐inspired artificial mechanoreceptor based on ionic interactions is presented for biomimetic tactile sensing. Pressure‐driven ionic redistribution within microfluidic channels generates a self‐powered electrical signal without external bias. The generated waveform exhibits mechanoreceptor‐like temporal features, including overshoot and undershoot,
Mohammad Akbari, Jeppe Don, Lasse A. N. Pedersen, John Noee, Rassoul Tabassian   +4 more
wiley   +1 more source

Poor maize productivity in Zimbabwe: Can collusion in pricing by seed houses be the cause?

Cogent Food & Agriculture, 2019
High cost of hybrid seed can affect food self-sufficiency. A study was conducted to investigate the structure, conduct and performance of the hybrid maize seed industry in Zimbabwe to determine whether the level of competition in the industry caused high
Handsen Tibugari, Tinei Chikasha, Ngonidzaishe Manyeruke, Ndabanye Mathema, Joseph P. Musara, Dumisa Dlamini, Rangarirai Mapuranga, Olga Mapanje, Annabel Banda, Cosmas Parwada   +9 more
doaj   +1 more source

Effect of Potassium on Growth, Yield and NPK Uptake of Hybrid Maize in Black Calcareous Soil

Madras Agricultural Journal, 2019
Potassium is one of the major nutritive element which will require greater attention in order to ensure grain yield and mitigation of biotic and abiotic stresses as well as improvement in quality of maize.
R. Gnanasundari, Sellamuthu K.M, Malathi P.   +2 more
doaj   +1 more source

High‐Modulus Skeleton‐Reinforced PDMS Microstamps for Precision Transfer Printing of Microscale Devices

Advanced Functional Materials, EarlyView.
Elastomeric micropillars bend under contact loading, sliding microscale devices out of alignment during transfer printing. A hybrid PDMS stamp embeds a high‐modulus skeleton within each pillar while retaining a compliant contact surface. The reinforcement confines pillar deformation, suppressing interfacial sliding and preserving array registration on ...
Seol Ahn, Yulin Zhou, Jeongmin Seo, Seong Woo Hong, Sungyeon Kim, Seohyeon Kim, Haechang Ryu, Raudel Avila, Yei Hwan Jung   +8 more
wiley   +1 more source