Results 61 to 70 of about 1,592,171 (301)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Synthesizing SystemC Code from Delay Hybrid CSP

, 2017
Delay is omnipresent in modern control systems, which can prompt oscillations and may cause deterioration of control performance, invalidate both stability and safety properties.
A Bellen, A Deshpande, A Girard, D Angeli, D Harel, E Ahmad, E Lee, G Pola, G Pola, G Yan, L Zou, M Anand, M Chen, M Fränzle, N Zhan, R Alur, TA Henzinger, Y Hur, Z Huang   +18 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Safe Neighborhood Computation for Hybrid System Verification

, 2015
For the design and implementation of engineering systems, performing model-based analysis can disclose potential safety issues at an early stage. The analysis of hybrid system models is in general difficult due to the intrinsic complexity of hybrid ...
Deng, Yi, Julius, Agung
core   +2 more sources

Combining mechanistic and data-driven techniques for predictive modelling of wastewater treatment plants [PDF]

, 2020
Mechanistic models are widely used for modelling of wastewater treatment plants. However, as they are based on simplified and incomplete domain knowledge, they often lack accurate predictive capabilities.
De Baets, Bernard, De Jaegher, Bram, Nopens, Ingmar, Quaghebeur, Ward   +3 more
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

MODELS OF SCENARIO FORECASTING OF ECONOMIC CRISES ON THE BASIS OF HYBRID APPROACH

Вестник Российского экономического университета имени Г. В. Плеханова, 2020
The present article studies a semi-parametrical method of macro-economic forecast in periods of sharp changes in economy put forward by the authors. Data blocks are chosen on the basis of clusterization methods, which are as close to the current economic
V. M. Savinova, S. A. Yarushev
doaj   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Applying Combined Approach of Sequential Floating Forward Selection and Support Vector Machine to Predict Financial Distress of Listed Companies in Tehran Stock Exchange Market [PDF]

تحقیقات مالی, 2018
Objective: Nowadays, financial distress prediction is one of the most important research issues in the field of risk management that has always been interesting to banks, companies, corporations, managers and investors.
Saeid Fallahpour, Reza Raei, Eisa Norouzian   +2 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source