Results 21 to 30 of about 24,289 (266)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A multi-agent collaborative framework with human-in-the-loop for well log interpretation and applications

Petroleum Exploration and Development
This paper proposes a multi-agent system centered on large language models to address the issues that traditional well log interpretation relies on expert experience and poses great difficulty in multi-disciplinary collaboration and constructs a digital ...
Zhangxing CHEN, Ruichen DING, Yang MENG, Yizheng LI, Junwei ZHANG, Liu CAO, Jian LI, Wenqi FAN, Yiyuan ZHANG, Liqiu WANG, Dongxiao ZHANG, Yuntian CHEN   +11 more
doaj   +1 more source

Reasoning with inconsistencies in hybrid MKNF knowledge bases [PDF]

Logic Journal of IGPL, 2012
This paper is concerned with the handling of inconsistencies occurring in the combination of description logics and rules, especially in hybrid MKNF knowledge bases. More precisely, we present a paraconsistent semantics for hybrid MKNF knowledge bases (called para-MKNF knowledge bases) based on four-valued logic as proposed by Belnap.
Shasha Huang, Qingguo Li, Pascal Hitzler
openaire   +3 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Hybrid Reasoning with Forest Logic Programs [PDF]

, 2009
Open Answer Set Programming (OASP) is an attractive framework for integrating ontologies and rules. Although several decidable fragments of OASP have been identified, few reasoning procedures exist. In this paper, we provide a sound, complete, and terminating algorithm for satisfiability checking w.r.t.
Cristina Feier, Stijn Heymans
openaire   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Coding Anti-Discrimination Jurisprudence: A Hybrid Computational Model of the Arlington Heights Test

Journal of Social Computing
The aim of this study is to understand the judicial reasoning process of anti-discrimination jurisprudence by utilizing a hybrid computational model.
Kevin S. Jobe
doaj   +1 more source

Building a Knowledge Base of Bridge Maintenance Using Knowledge Graph

Advances in Civil Engineering, 2023
To effectively manage the heterogeneous and discrete knowledge of the bridge maintenance domain, this study adopts knowledge graph technology to build a knowledge base of bridge maintenance, called the bridge maintenance knowledge graph (BMKG).
Yang Zhang, Jia Liu, Kepeng Hou
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source