Results 41 to 50 of about 61,924 (266)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A genetic bistable switch utilizing nonlinear protein degradation

Journal of Biological Engineering, 2012
Background Bistability is a fundamental property in engineered and natural systems, conferring the ability to switch and retain states. Synthetic bistable switches in prokaryotes have mainly utilized transcriptional components in their construction ...
Huang Daniel, Holtz William J, Maharbiz Michel M   +2 more
doaj   +1 more source

An optimized parameter design method of SiC/Si hybrid switch considering turn-off current spike

Energy Reports, 2022
In order to reduce the switching loss of SiC MOSFET/Si IGBT (SiC/Si) hybrid switch, the switching mode that turn off the Si IGBT prior to the SiC MOSFET is generally adopted to achieved the zero-voltage switching operation of IGBT.
Haihong Qin, Sixuan Xie, Qian Xun, Fanghua Zhang, Zhenxiang Xu, Lingyan Wang   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Current control of Z-source inverter for hybrid energy storage system of mine-used electric vehicle

Gong-kuang zidonghua, 2019
Aiming at problems of low voltage gain, low power density and low conversion efficiency of traditional Z-source inverter or single-switch inductor Z-source inverter used in hybrid energy storage system of mine-used electric vehicle, a novel Z-source ...
WU Zhen, CHEN Jing, DANG Jiao
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Optical Switch Based on Ge₂Sb₂Se₄Te₁-Assisted Racetrack Microring

Photonics, 2022
In this work, we have proposed and designed a 1 × 1 optical switch based on the optical phase-change material, Ge2Sb2Se4Te1 (GSST), for GSST-assisted silicon racetrack microring.
Yan Xu, Songyue Liu, Tingyu Liu, Yang Gao, Yuexin Yin, Xiaoqiang Sun, Daming Zhang   +6 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Automatic Transfer Switch (ATS) for Floating Lift Net Powered by Hybrid Energy Source [PDF]

E3S Web of Conferences
The increasing demand for renewable energy as an alternative to fossil fuels has driven innovations in hybrid power systems. This study focuses on optimizing a hybrid energy system for a floating lift net utilizing solar panels (photovoltaic) and a ...
Hariyanto Surya, Lobo’ Darmin, Mahmuddin Faisal, Klara Syerly   +3 more
doaj   +1 more source