Results 141 to 150 of about 80,361 (310)

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

Methodology to Improve an Extended-Range Electric Vehicle Module and Control Integration Based on Equivalent Consumption Minimization Strategy

World Electric Vehicle Journal
The continuous expansion of the vehicle fleet contributes to escalating emissions, with the transportation sector accounting for approximately 21% of CO2 emissions, based on 2023 data. Focused on reducing emissions and reliance on fossil fuels, the study
David Sebastian Puma-Benavides, Juan de Dios Calderon-Najera, Javier Izquierdo-Reyes, Renato Galluzzi, Edilberto Antonio Llanes-Cedeño   +4 more
doaj   +1 more source

Development and use of a hybrid electric vehicle (HEV) model for interactive customer assessment of sound quality : innovation report [PDF]

With the increasing adoption and usage of hybrid electric vehicle (HEV) technologies, there is a growing recognition that attributes such as dynamics, driveability and refinement can have an adverse affect on customer acceptance. There are a number of
Poxon, John E. W.
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Parameter estimation for non-linear systems: an application to vehicle dynamics [PDF]

, 2009
This work presents an investigation into the parameter estimation of suspension components and the vertical motions of wheeled vehicles from experimental data.
Pedchote, C.
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Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Analysis of Energy Efficiency Parameters of a Hybrid Vehicle Powered by Fuel with a Liquid Catalyst

Energies
A notable trend in the modern automotive market is the increased interest in hybrid cars. Hybrid cars combine a standard internal combustion engine with an electric motor solution.
Tomasz Osipowicz, Wawrzyniec Gołębiewski, Wojciech Lewicki, Adam Koniuszy, Karol Franciszek Abramek, Konrad Prajwowski, Oleh Klyus, Dominik Gałdyński   +7 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Modeling the deployment of plug-in hybrid and electric vehicles and their effects on the Australian National Electricity Market. [PDF]

The development of hybrid and fully electric vehicles could deliver significant reductions of emissions from the Australian transportation sector by shifting its major energy source from internal combustion to electricity.
Liam Wagner, Luke Reedman
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A Triple‐Nanoparticle System for Controlled Graphene Nanosheet Stacking: Enabling K/Na‐Ion Battery Anodes with Ultra‐Fast Charging Exceeding Petroleum Vehicle Refueling

Advanced Science, EarlyView.
ABSTRACT Large‐ion (K, Na) battery systems mitigate uneven global lithium distribution, while their ability to attain recharge time shorter than refueling would remove the final barrier for secondary batteries to replace petroleum vehicles. However, their large‐ion chemistry makes ultra‐fast charging an even significant challenge.
Shukai Ding, Le Zhang, Hang Li, Yang Zhang, Guoquan Suo, Bin Han, Dongfeng Sun, Wenqi Zhao, Gaohui Du, Qingmei Su, Bingshe Xu, Zhen Xu, Wei Wang   +12 more
wiley   +1 more source

A Purely Mechanical Energy Storing Concept for Hybrid Vehicles

, 2003
The paper contains the design and simulation of a purely mechanical system for storing energy during vehicle deceleration, which can be utilized during subsequent acceleration (regenerative braking).
Tchobansky, Latchezar, Schlager, Gerd, Kozek, Martin, Jörgl, Hanns Peter   +3 more
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