Results 101 to 110 of about 6,400,137 (318)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Map of Persia & Afghanistan [cartographic material].

, 1906
Map of Persia and Afghanistan showing international boundaries, transportation, communication, water features and populated places. Relief shown by hypsometric tints and spot heights.; "Topographic Section, General staff No.
Great Britain. War Office.
core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Hybrid Peace/War

, 2018
It is intuitive to view peace and war as inherently opposite categories. Peace is routinely defined as the freedom from organised collective violence, or as the ‘absence of war’. Conversely, war is generally conceived either in Clausewitzian terms as organised violence to achieve political ends or as a moral or legal condition defining the permissible ...
openaire   +3 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Russophobia as a Component of Modern Geopolitical Confrontation: Global and Regional Dimensions

Регионология
Introduction. The relevance of the study is due to the unprecedented scale and consequences of modern manifestations of Western Russophobia, which are sources of not only external but also internal challenges and threats to Russia’s national security ...
Petr I. Pashkovsky, Evgeniy V. Kryzhko, Lydia A. Kryzhko   +2 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

"A Change of Paradigm" in Developing Land Forces Officers' Professional Skills in Accordance with Hybrid Warfare Task-Requirements [PDF]

Journal of Defense Resources Management, 2016
In future conflicts, not only traditional or asymmetric actions will be used, but also a combination of the two in order to solve the disputes involving national and international actors, materialized today in different manifestation forms called ...
Alexandru Rizescu, Florian Ciocan
doaj  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Hybrid War and the National Security of Russia

Humanities and Social Sciences Bulletin of the Financial University, 2019
The article is devoted to the military conflicts of the XXI century and the existing approaches to their understanding of the foreign and domestic scientific literature.
V. Rodachin
semanticscholar   +1 more source