Results 41 to 50 of about 12,680 (259)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

THE TOOLS OF “HYBRID WARS”: LAWFARE

Вісник Національного університету оборони України, 2021
У статті «Засоби «гібридних воєн»: правовійна» на основі огляду сучасної західної літератури проаналізовано таку форму репрезентації відсутності нейтральності права як «правовійна». У розділі «Визначення головної проблеми» зазначено, що важливим компонентом сучасних «гібридних воєн» є зловживання правовими нормами; міра цих зловживань та способи їх ...
openaire   +4 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

POLITICAL CARICATURE AS AN ELEMENT OF RUSSIA'S HYBRID WAR AGAINST UKRAINE (2014-2022)

Вісник Харківського національного університету імені В. Н. Каразіна: Серія "Питання політології"
The article deals with the political caricature of Russia in the Russian-Ukrainian war (2014-2022). It is shown that since 2014, Russia has systematically and consistently implemented a hybrid war against Ukraine, in which political actions were more ...
Oleg Gaiko, Oksana Chaika
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

To the Issue of Network-Centric Format of Hybrid of War of the XXI Century

Управленческое консультирование, 2018
The article focuses on the place of network-centric war in the structure of the modern hybrid war. The author gives a definition of hybrid war and examines the cognitive aspects of the information sector of network-centrism.
Sergey Yuryevich Chimarov
doaj  

Ukrainian Hybrid War – Quo Vadis?

Buletinul Ştiinţific al Academiei Trupelor de Uscat, 2015
Although it is known for a long time, hybrid war taken place in Ukraine under the umbrella of Russian Federation surprised the whole world and produced the greatest worry for humankind’s fate since the World War II.
Rotărescu Carmen
doaj   +1 more source

Determination and Development of Definitions and Concepts of Hybrid Threats and Hybrid Wars: Comparison of Solutions at the Level of the European Union, NATO and Croatia

Politics in Central Europe, 2022
Political, professional and academic circles, as well as the general public, are increasingly using different terms like hybrid threats and hybrid wars in everyday circumstances, describing different phenomena and processes.
Mikac Robert
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source