Results 51 to 60 of about 119,555 (267)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

DNA Identification and Diversity of the Vector Mosquitoes Culex pipiens s.s. and Culex torrentium in Belgium (Diptera: Culicidae)

Diversity, 2022
This survey reports on the DNA identification and occurrence of Culex torrentium and Cx. pipiens s.s. in Belgium. These native disease-vector mosquito species are morphologically difficult to separate, and the biotypes of Cx. pipiens s.s.
Ann Vanderheyden, Nathalie Smitz, Katrien De Wolf, Isra Deblauwe, Wouter Dekoninck, Kenny Meganck, Sophie Gombeer, Adwine Vanslembrouck, Jacobus De Witte, Anna Schneider, Ingrid Verlé, Marc De Meyer, Thierry Backeljau, Ruth Müller, Wim Van Bortel   +14 more
doaj   +1 more source

Hybridization of Institutions [PDF]

, 2011
Modal logics are successfully used as specification logics for reactive systems. However, they are not expressive enough to refer to individual states and reason about the local behaviour of such systems. This limitation is overcome in hybrid logics which introduce special symbols for naming states in models.
Manuel A. Martins 0001, Alexandre Madeira, Razvan Diaconescu, Luís Soares Barbosa   +3 more
openaire   +3 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Estimation of the surface tension and dispersive and polar components of polymers as a function of temperature for composite manufacturing applications

Polymer Testing
Understanding adhesion between fiber and matrix at elevated temperatures is essential for improving the mechanical performance of polymer-based composites, especially with thermoplastic matrices.
Rami Alawar, Pierre-Jacques Liotier, Romain Ravel, Monica Francesca Pucci   +3 more
doaj   +1 more source

Synthesis and Antiproliferative Activity of Novel Dehydroabietic Acid-Chalcone Hybrids

Molecules, 2022
Dehydroabietic Acid (DHA, 1) derivatives are known for their antiproliferative properties, among others. In the context of this work, DHA was initially modified to two key intermediates bearing a C18 methyl ester, a phenol moiety at C12, and an acetyl or
Sophia Grigoropoulou, Dimitra Manou, Antonia I. Antoniou, Artemis Tsirogianni, Carlo Siciliano, Achilleas D. Theocharis, Constantinos M. Athanassopoulos   +6 more
doaj   +1 more source

On Hybrid Dogs [PDF]

Science, 1887
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openaire   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Hybrid Porous Crystalline Materials from Metal Organic Frameworks and Covalent Organic Frameworks

Advanced Science, 2021
Two frontier crystalline porous framework materials, namely, metal‐organic frameworks (MOFs) and covalent organic frameworks (COFs), have been widely explored owing to their outstanding physicochemical properties. While each type of framework has its own
Ziman Chen, Xinle Li, Chongqing Yang, Kaipeng Cheng, Tianwei Tan, Yongqin Lv, Yi Liu   +6 more
doaj   +1 more source

Studies of Potency and Efficacy of an Optimized Artemisinin-Quinoline Hybrid against Multiple Stages of the Plasmodium Life Cycle

Pharmaceuticals, 2021
A recently developed artemisinin-quinoline hybrid, named 163A, has been shown to display potent activity against the asexual blood stage of Plasmodium, the malaria parasite.
Helenita C. Quadros, Aysun Çapcı, Lars Herrmann, Sarah D’Alessandro, Diana Fontinha, Raquel Azevedo, Wilmer Villarreal, Nicoletta Basilico, Miguel Prudêncio, Svetlana B. Tsogoeva, Diogo R. M. Moreira   +10 more
doaj   +1 more source