Results 41 to 50 of about 21,141 (225)

Рассказ о Вавилонской башне (Быт 11:1–9). Новый перевод и комментарий

Вестник Свято-Филаретовского института
Рассказ о Вавилонской башне (Быт 11:1–9) — один из ключевых эпизодов в повествовании книги Бытия. В современной науке предлагаются различные, подчас сильно расходящиеся, датировки данной перикопы, а также различные трактовки ее места в той картине ...
Селезнев, М.Г., Луппова, А.А.   +1 more
doaj   +1 more source

Let Your Kingdom Come: Justice as an Absent Driving Force in Legal Education

Derecho PUCP, 2018
This paper proposes an approach to justice as a driving force which moves people towards rectitude, balance and harmony. The hybris is presented as the opposite force, one that animates the subject towards perversion, domination and discord.
Fernando Del Mastro Puccio
doaj   +1 more source

THE ANTHROPOLOGICAL CONSEQUENCES OF THE EVOLUTION OF EMPIRICISM [PDF]

, 2012
[The text examines methodological consequences of anti-metaphysical turn of British empiricism in the field of anthropology. I argue that this shift reinforces anthropology in its descriptive and interdisciplinary form, because destruction of ...
Misztal, Dawid
core   +1 more source

Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein

Advanced Science, Volume 12, Issue 27, July 17, 2025.
Hendra and Nipah viruses (HNVs) pose significant threats to global health. This work reports potent cross‐neutralizing antibodies targeting the fusion glycoprotein (F) and reveals shared features of these antibodies and vulnerabilities of F, thereby guiding the rational design of countermeasures against HNVs and similar pathogens.
Yi Ren, Pengfei Fan, Xinghai Zhang, Ting Fang, Zhengshan Chen, Yanfeng Yao, Xiangyang Chi, Guanying Zhang, Xiaofan Zhao, Bingjie Sun, Fangxu Li, Zixuan Liu, Zhenwei Song, Baoyue Zhang, Cheng Peng, Entao Li, Yilong Yang, Jianmin Li, Sandra Chiu, Changming Yu   +19 more
wiley   +1 more source

Proteostasis Disruption by Proteasome Inhibitor MG132 and Propolin G Induces ER Stress‐ and Autophagy‐Mediated Apoptosis in Breast Cancer

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
Combination treatment with MG132 and propolin G, a c‐prenylflavanone from Taiwanese propolis, synergistically suppressed proteasome activity, leading to proteotoxic stress‐mediated apoptosis in breast cancer. This combination treatment triggers apoptosis by activating the PERK‐mediated unfolded protein response (UPR) pathway.
Jih‐Tung Pai, Lei‐Po Chen, Hsuan‐Jui Chang, Shih‐Wei Wang, Yann‐Lii Leu, Cheng‐Ta Lai, Meng‐Shih Weng   +6 more
wiley   +1 more source

Lamellarin D Acts as an Inhibitor of Type I Collagen Production

ChemMedChem, Volume 20, Issue 9, May 5, 2025.
COL1A2 gene, encoding type I collagen, is a key target for pulmonary fibrosis. We established a screening system to identify small molecules that inhibit COL1A2 gene expression. Using this system, we screen a library of compounds and identify lamellarin D as a potent inhibitor of COL1A2 expression, suggesting lamellarin D is a promising new lung ...
Daisuke Okuno, Noriho Sakamoto, Hideki Hayashi, Tsutomu Fukuda, Yoshiko Akiyama, Chiaki Iketani, Ritsuko Murakami, Takatomo Tokito, Takuto Miyamura, Hirokazu Yura, Takashi Kido, Hiroshi Ishimoto, Shinnosuke Takemoto, Takahiro Takazono, Tomoya Nishino, Yuji Ishimatsu, Jun Ishihara, Kohsuke Takeda, Yoshimasa Tanaka, Hiroshi Mukae   +19 more
wiley   +1 more source

Today Through the Lens of the Ancient Debate on the Value of Mētis

Hybris
In Today Through the Lens of the Ancient Debate on the Value of Mētis, the author examines contemporary challenges to freedom of speech in art, science, and politics through the ancient Greek concept of mētis—practical wisdom enabling success in life ...
Petr Slováček
doaj   +1 more source

Apocalypses and the Sage. Different Endings of the World in Seneca [PDF]

, 2019
This paper deals with apocalypse, intended as a revelation or prediction related to the end of the world, in Seneca’s prose work. The descriptions and readings of this event appear to be quite different from each other. My analysis will
Berno, FRANCESCA ROMANA
core   +2 more sources

HDAC2‐Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple‐Negative Breast Cancer

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This study identifies the lactylation modification of methyltransferase‐like 3 (METTL3) in breast tumors and its delactylase histone deacetylase 2 (HDAC2). It elucidates the molecular mechanism by which HDAC2‐mediated METTL3 delactylation promotes triple‐negative breast cancer (TNBC) resistance to cisplatin through upregulation of DNA damage repair ...
Xiaoniu He, Yuanpei Li, Jian Li, Yu Li, Sijie Chen, Xia Yan, Zhangrong Xie, Jiangfeng Du, Guoan Chen, Jianbo Song, Qi Mei   +10 more
wiley   +1 more source

Liberation and passion: reconstructing the passion perspective on human being and freedom [PDF]

, 2002
Many contemporary philosophers tell us that we are essentially purposeful, independent, willing, and acting beings. The self is presented as a citadel defending itself against external, alien influences. Alternatively, some argue that we are the sum of a
Coeckelbergh, Mark
core   +2 more sources