Results 231 to 240 of about 22,486 (258)
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Acta Medica Scandinavica, 1981
In summary, there investigations indicate that oral hydralazine produces beneficial hemodynamic effects in patients with chronic CHF. These favorable hemodynamic response are observed in the presence or absence of mechanical defects, such as mitral or aortic regurgitation.
Jean-Lucien Rouleau +2 more
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In summary, there investigations indicate that oral hydralazine produces beneficial hemodynamic effects in patients with chronic CHF. These favorable hemodynamic response are observed in the presence or absence of mechanical defects, such as mitral or aortic regurgitation.
Jean-Lucien Rouleau +2 more
openaire +2 more sources
Hydralazine and furosemide kinetics
Clinical Pharmacology and Therapeutics, 1982Fursosemide kinetics were studied in 25 patients with congestive heart failure. The elimination half-life (t1/2) was longer and the elimination rate constant and the plasma clearance smaller in patients with advanced (n = 15) than in those with moderate (n = 10) failure.
Kunihiko Katoh +5 more
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Hydralazine pharmacodynamics in the dog
American Journal of Veterinary Research, 1983SUMMARY The pharmacodynamics of hydralazine, an arteriolar dilator, were studied in dogs with induced heart failure. The dogs were studied 5 days after heart failure was induced by injecting microspheres into the left circumflex coronary artery. All dogs had a stroke volume index < 25 ml/beat/m2 of body surface and a left ventricular filling ...
M D, Kittleson, R L, Hamlin
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Endogenous generation of hydralazine from labile hydralazine hydrazones.
The Journal of Pharmacology and Experimental Therapeutics, 1982The hypothesis that the pharmacologically active hydralazine hydrazones (HH) are endogenously hydrolyzed to parent hydralazine (H) was tested in a series of in vitro and in vivo systems. The stable hydrazones H alpha-ketoglutaric acid hydrazone and H pyruvic acid hydrazone did not hydrolyze to H in vitro (buffer or plasma), were inactive in vivo and ...
W A, Clementi +5 more
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Hydralazine-Pyrimidine Interactions May Explain Hydralazine-Induced Lupus Erythematosus
Science, 1980Hydralazine, the prototypic drug that induces systemic lupus erythematosus, reacts with thymidine and deoxycytidine. Analysis of a reaction mixture of therapeutic concentrations of hydralazine with labeled thymidine reveals at least four labeled products.
Robert J. Reid, Lewis M. Dubroff
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Hydralazine-induced liver injury
Digestive Diseases and Sciences, 1980A 68-year-old man developed hepatic injury with no hypersensitivity reaction after three years of hydralazine therapy. The liver injury histologically showed centrilobular zonal necrosis. Clinical, biochemical, and histological recovery followed discontinuation of the drug.
Susumu Itoh +3 more
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Immune Responses to Hydralazine and Nuclear Antigens in Hydralazine-Induced Lupus Erythematosus
Annals of Internal Medicine, 1972Abstract Immune responses to hydralazine were detected in patients with hydralazine-induced lupus but not in patients taking hydralazine without developing toxicity, patients with systemic lupus er...
Owen S. Kantor +7 more
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Hydralazine-induced constrictive pericarditis
The Netherlands Journal of Medicine, 1996A 59-year-old man was diagnosed as having constrictive pericarditis 17 months after a typical hydralazine-induced autoimmune syndrome. This late complication of hydralazine has been reported only once. Ten years later the patient was found to have anti-neutrophil cytoplasmic antibodies directed against myeloperoxidase.
M.I.H. El Gamal +3 more
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Hydralazine for essential hypertension
2010Hypertension is associated with an increased risk of stroke, myocardial infarction and congestive heart failure. Hydralazine is a direct-acting vasodilator which has been used for the treatment of hypertension since the 1950's. Although it has largely been replaced by newer antihypertensive drugs with more acceptable tolerability profiles, hydralazine ...
Michael R, Kandler +3 more
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Electrophysiologic Properties of Hydralazine in Man
Pacing and Clinical Electrophysiology, 1980There is considerable interest in selecting the proper drug to preserve the ischemic myocardium, or twilight zone, in a patient with a recent myocardial infarction, Vasodilator therapy with an infusion of nitroprusside1 or phentolamine2,3 has been shown to improve left ventricular function by reducing both preload and afterload.
William H. Becker +4 more
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