Results 41 to 50 of about 170,094 (295)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Escape of methane gas from the seabed along the West Spitsbergen continental margin [PDF]

, 2009
More than 250 plumes of gas bubbles have been discovered emanating from the seabed of the West Spitsbergen continental margin, in a depth range of 150-400 m, at and above the present upper limit of the gas hydrate stability zone (GHSZ).
Nisbet, Euan G., Crocker, A. J., Pälike, H, Pälike, H., Green, Darryl,, Beszczynska-Möller, Agnieszka, Westbrook, Graham, Osborne, AH, Green, D, Rohling, Eelco J., Fisher, R. E., Beszczynska-Möller, Alfred, Lanoisellé, M., Minshull, TA, Nisbet, EG, Chabert, A, Nisbet, E. G., Minshull, Tim A., Crocker, Anya J., Rohling, Eelco, Kuhnt, Wolfgang, James, RH, Berndt, C, Thatcher, Kate E., Piotrowski, A. M., Piotrowski, Alexander, Westbrook, G. K., Fisher, Rebecca E., Huhnerbach, Veit, Hühnerbach, V., Lanoisellé, M, Westbrook, Graham K., Aquilina, Alfred, Fisher, RE, Thatcher, Kate, Crocker, AJ, Gisbet, Euan G., Berndt, C., Bolton, Clara, Bolton, C, Green, D., James, Rachael H., Rohling, E. J., Green, Darryl, Osborne, Anne, Pälike, Heiko, Minshull, T. A., Aquilina, A, Beszczynska-Möller, A, Green, Darryl, R.H., James, R. H., Clemens, Steven, Osborne, Anne H., Green, Daryll, Chabert, A., Aquilina, A., Lanoisellé, Mathias, Bolton, C., Osborne, A. H., Rohling, EJ, Chabert, Anne, Berndt, Christian, Thatcher, K. E., Piotrowski, Alexander M., Piotrowski, AM, Beszczynska-Möller, A., Hühnerbach, V   +66 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Investigations on a controlled microwave heating technique for efficient depressurization in methane hydrate reservoirs

Energy Reports, 2022
Numerical investigations on a novel technique of controlled microwave heating with depressurization, applied to gas recovery from methane hydrate reservoirs are performed.
Rahul Yadav, Akash K. Gupta, Malay K. Das, P.K. Panigrahi   +3 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Biogeochemical Reconstruction of Authigenic Carbonate Deposits at Methane Seep Site off Krishna‐Godavari (K‐G) Basin, Bay of Bengal

Geochemistry, Geophysics, Geosystems
Active and relic marine methane‐seep sites are widely distributed globally and are distinguished by distinctive geology, biogeochemistry, and ecosystems.
S. P. K. Pillutla, A. Peketi, A. Mazumdar, Mohd. Sadique, K. Sivan, Anjali Zatale, S. Mishra, Swati Verma   +7 more
doaj   +1 more source

Investigation of Gas-Water-Sand Fluid Resistivity Property as Potential Application for Marine Gas Hydrate Production

Entropy, 2022
The phase fraction measurement of gas-water-sand fluid in downhole is an important premise for safe and stable exploitation of natural gas hydrates, but the existing phase fraction measurement device for oil and natural gas exploitation can’t be directly
Zhiwen Zhang, Xiaosen Li, Zhaoyang Chen, Yu Zhang, Hao Peng   +4 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Study on crystallization of tetrahydrofuran hydrate and rheological properties of its slurry

You-qi chuyun
Objective Hydrate slurry transportation offers an effective way to save on reagent costs and is expected to be utilized as a safe, economical, and efficient mode for transporting natural gas through submarine pipelines.
Zhenqiang XIE, Qingping LI, Shuo YANG, Haiyuan YAO, Rui QIN   +4 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source